Advanced image processing for optical coherence tomographic angiography of macular diseases

Miao Zhang, Jie Wang, Alex D. Pechauer, Thomas Hwang, Simon S. Gao, Liang Liu, Li Liu, Steven Bailey, David Wilson, David Huang, Jia Yali

Research output: Contribution to journalArticle

79 Citations (Scopus)

Abstract

This article provides an overview of advanced image processing for three dimensional (3D) optical coherence tomographic (OCT) angiography of macular diseases, including age-related macular degeneration (AMD) and diabetic retinopathy (DR). A fast automated retinal layers segmentation algorithm using directional graph search was introduced to separates 3D flow data into different layers in the presence of pathologies. Intelligent manual correction methods are also systematically addressed which can be done rapidly on a single frame and then automatically propagated to full 3D volume with accuracy better than 1 pixel. Methods to visualize and analyze the abnormalities including retinal and choroidal neovascularization, retinal ischemia, and macular edema were presented to facilitate the clinical use of OCT angiography.

Original languageEnglish (US)
Article number250610
Pages (from-to)4661-4675
Number of pages15
JournalBiomedical Optics Express
Volume6
Issue number12
DOIs
StatePublished - Nov 2 2015

Fingerprint

angiography
image processing
Angiography
Retinal Neovascularization
ischemia
angiogenesis
edema
Choroidal Neovascularization
Papilledema
Macular Edema
Three-Dimensional Imaging
degeneration
abnormalities
Macular Degeneration
pathology
Diabetic Retinopathy
Ischemia
pixels
Pathology

Keywords

  • Image analysis
  • Image processing
  • Ophthalmology
  • Optical coherence tomography

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Biotechnology

Cite this

Advanced image processing for optical coherence tomographic angiography of macular diseases. / Zhang, Miao; Wang, Jie; Pechauer, Alex D.; Hwang, Thomas; Gao, Simon S.; Liu, Liang; Liu, Li; Bailey, Steven; Wilson, David; Huang, David; Yali, Jia.

In: Biomedical Optics Express, Vol. 6, No. 12, 250610, 02.11.2015, p. 4661-4675.

Research output: Contribution to journalArticle

Zhang, Miao ; Wang, Jie ; Pechauer, Alex D. ; Hwang, Thomas ; Gao, Simon S. ; Liu, Liang ; Liu, Li ; Bailey, Steven ; Wilson, David ; Huang, David ; Yali, Jia. / Advanced image processing for optical coherence tomographic angiography of macular diseases. In: Biomedical Optics Express. 2015 ; Vol. 6, No. 12. pp. 4661-4675.
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