Abstract
Voltage-gated potassium channels are widely expressed throughout the entire nervous system. These channels play a critical role in establishing the resting membrane potential and generation of neuronal action potentials. There is mounting evidence that autoantibodies reactive to neuronal cell surface antigens, such as voltage-gated potassium channels, play a pathogenic role in a wide spectrum of central and peripheral nervous system disorders. We report a case of new-onset drug-refractory seizure disorder associated with the presence of high levels of serum anti - voltage-gated potassium channel antibodies that responded only to immunotherapy. As demonstrated by this case report, anti - voltage-gated potassium channel antibody associated drug-refractory seizure disorder, although rare, should be considered in patients with unexplained adult-onset seizure activity. Once the diagnosis has been established the initiation of immunotherapy should be undertaken without delay.
Original language | English (US) |
---|---|
Pages (from-to) | 473-477 |
Number of pages | 5 |
Journal | Epilepsia |
Volume | 51 |
Issue number | 3 |
DOIs | |
State | Published - Mar 2010 |
Externally published | Yes |
Keywords
- Anti-VGKC antibody
- Encephalopathy
- Limbic encephalitis
- Seizure disorder
ASJC Scopus subject areas
- Neurology
- Clinical Neurology