Abstract
Voltage-gated potassium channels are widely expressed throughout the entire nervous system. These channels play a critical role in establishing the resting membrane potential and generation of neuronal action potentials. There is mounting evidence that autoantibodies reactive to neuronal cell surface antigens, such as voltage-gated potassium channels, play a pathogenic role in a wide spectrum of central and peripheral nervous system disorders. We report a case of new-onset drug-refractory seizure disorder associated with the presence of high levels of serum anti - voltage-gated potassium channel antibodies that responded only to immunotherapy. As demonstrated by this case report, anti - voltage-gated potassium channel antibody associated drug-refractory seizure disorder, although rare, should be considered in patients with unexplained adult-onset seizure activity. Once the diagnosis has been established the initiation of immunotherapy should be undertaken without delay.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 473-477 |
| Number of pages | 5 |
| Journal | Epilepsia |
| Volume | 51 |
| Issue number | 3 |
| DOIs | |
| State | Published - Mar 2010 |
| Externally published | Yes |
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Keywords
- Anti-VGKC antibody
- Encephalopathy
- Limbic encephalitis
- Seizure disorder
ASJC Scopus subject areas
- Clinical Neurology
- Neurology
Cite this
Adult-onset drug-refractory seizure disorder associated with anti-voltage-gated potassium-channel antibody. / Barajas, Ramon; Collins, D. Eric; Cha, Soonmee; Geschwind, Michael D.
In: Epilepsia, Vol. 51, No. 3, 03.2010, p. 473-477.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Adult-onset drug-refractory seizure disorder associated with anti-voltage-gated potassium-channel antibody
AU - Barajas, Ramon
AU - Collins, D. Eric
AU - Cha, Soonmee
AU - Geschwind, Michael D.
PY - 2010/3
Y1 - 2010/3
N2 - Voltage-gated potassium channels are widely expressed throughout the entire nervous system. These channels play a critical role in establishing the resting membrane potential and generation of neuronal action potentials. There is mounting evidence that autoantibodies reactive to neuronal cell surface antigens, such as voltage-gated potassium channels, play a pathogenic role in a wide spectrum of central and peripheral nervous system disorders. We report a case of new-onset drug-refractory seizure disorder associated with the presence of high levels of serum anti - voltage-gated potassium channel antibodies that responded only to immunotherapy. As demonstrated by this case report, anti - voltage-gated potassium channel antibody associated drug-refractory seizure disorder, although rare, should be considered in patients with unexplained adult-onset seizure activity. Once the diagnosis has been established the initiation of immunotherapy should be undertaken without delay.
AB - Voltage-gated potassium channels are widely expressed throughout the entire nervous system. These channels play a critical role in establishing the resting membrane potential and generation of neuronal action potentials. There is mounting evidence that autoantibodies reactive to neuronal cell surface antigens, such as voltage-gated potassium channels, play a pathogenic role in a wide spectrum of central and peripheral nervous system disorders. We report a case of new-onset drug-refractory seizure disorder associated with the presence of high levels of serum anti - voltage-gated potassium channel antibodies that responded only to immunotherapy. As demonstrated by this case report, anti - voltage-gated potassium channel antibody associated drug-refractory seizure disorder, although rare, should be considered in patients with unexplained adult-onset seizure activity. Once the diagnosis has been established the initiation of immunotherapy should be undertaken without delay.
KW - Anti-VGKC antibody
KW - Encephalopathy
KW - Limbic encephalitis
KW - Seizure disorder
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U2 - 10.1111/j.1528-1167.2009.02287.x
DO - 10.1111/j.1528-1167.2009.02287.x
M3 - Article
VL - 51
SP - 473
EP - 477
JO - Epilepsia
JF - Epilepsia
SN - 0013-9580
IS - 3
ER -