Adult-onset drug-refractory seizure disorder associated with anti-voltage-gated potassium-channel antibody

Ramon Barajas, D. Eric Collins, Soonmee Cha, Michael D. Geschwind

Research output: Contribution to journalArticle

59 Citations (Scopus)

Abstract

Voltage-gated potassium channels are widely expressed throughout the entire nervous system. These channels play a critical role in establishing the resting membrane potential and generation of neuronal action potentials. There is mounting evidence that autoantibodies reactive to neuronal cell surface antigens, such as voltage-gated potassium channels, play a pathogenic role in a wide spectrum of central and peripheral nervous system disorders. We report a case of new-onset drug-refractory seizure disorder associated with the presence of high levels of serum anti - voltage-gated potassium channel antibodies that responded only to immunotherapy. As demonstrated by this case report, anti - voltage-gated potassium channel antibody associated drug-refractory seizure disorder, although rare, should be considered in patients with unexplained adult-onset seizure activity. Once the diagnosis has been established the initiation of immunotherapy should be undertaken without delay.

Original languageEnglish (US)
Pages (from-to)473-477
Number of pages5
JournalEpilepsia
Volume51
Issue number3
DOIs
StatePublished - Mar 2010
Externally publishedYes

Fingerprint

Voltage-Gated Potassium Channels
Epilepsy
Antibodies
Pharmaceutical Preparations
Immunotherapy
Central Nervous System Diseases
Peripheral Nervous System Diseases
Surface Antigens
Membrane Potentials
Autoantibodies
Nervous System
Action Potentials
Seizures
Serum

Keywords

  • Anti-VGKC antibody
  • Encephalopathy
  • Limbic encephalitis
  • Seizure disorder

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Adult-onset drug-refractory seizure disorder associated with anti-voltage-gated potassium-channel antibody. / Barajas, Ramon; Collins, D. Eric; Cha, Soonmee; Geschwind, Michael D.

In: Epilepsia, Vol. 51, No. 3, 03.2010, p. 473-477.

Research output: Contribution to journalArticle

Barajas, Ramon ; Collins, D. Eric ; Cha, Soonmee ; Geschwind, Michael D. / Adult-onset drug-refractory seizure disorder associated with anti-voltage-gated potassium-channel antibody. In: Epilepsia. 2010 ; Vol. 51, No. 3. pp. 473-477.
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