Adult growth hormone deficiency in patients with fibromyalgia.

Robert (Rob) Bennett

    Research output: Contribution to journalArticle

    56 Citations (Scopus)

    Abstract

    Adult growth hormone (GH) deficiency is a well-described clinical syndrome with many features reminiscent of fibromyalgia. There is evidence that GH deficiency as defined in terms of a low insulin-like growth factor-1 (IGF-1) level occurs in approximately 30% of patients with fibromyalgia and is probably the cause of some morbidity. It seems most likely that impaired GH secretion in fibromyalgia is related to a physiologic dysregulation of the hypothalamic-pituitary-adrenal axis (HPA) with a resulting increase in hypothalamic somatostatin tone. It is postulated that impaired GH secretion is secondary to chronic physical and psychological stressors. It appears that impaired GH secretion is more common than clinically significant GH deficiency with low IGF-1 levels. The severe GH deficiency that occurs in a subset of patients with fibromyalgia is of clinical relevance because it is a treatable disorder with demonstrated benefits to patients.

    Original languageEnglish (US)
    Pages (from-to)306-312
    Number of pages7
    JournalCurrent Rheumatology Reports
    Volume4
    Issue number4
    StatePublished - Aug 2002

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    Fibromyalgia
    Growth Hormone
    Somatomedins
    Somatostatin
    Psychology
    Morbidity

    ASJC Scopus subject areas

    • Rheumatology

    Cite this

    Adult growth hormone deficiency in patients with fibromyalgia. / Bennett, Robert (Rob).

    In: Current Rheumatology Reports, Vol. 4, No. 4, 08.2002, p. 306-312.

    Research output: Contribution to journalArticle

    Bennett, Robert (Rob). / Adult growth hormone deficiency in patients with fibromyalgia. In: Current Rheumatology Reports. 2002 ; Vol. 4, No. 4. pp. 306-312.
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