Adrenocorticotropin-cortisol axis abnormalities in hemodialysis patients

Walter J. McDonald, Thomas A. Golper, Robert D. Mass, John W. Kendall, George A. Porter, Donald E. Girard, Mark D. Fischer

Research output: Contribution to journalArticle

58 Scopus citations

Abstract

The ACTH-cortisol axis was studied in 15 hemodialysis patients. Basal plasma cortisol concentrations were found to be elevated and ACTH to be in the high normal range. Cortisol responded normally to exogenous ACTH, but neither cortisol nor ACTH were suppressed in response to oral dexamethasone. 11-Deoxycortisol and ACTH concentrations did not rise normally in response to either oral or iv metyrapone. We conclude that standard testing of the ACTH-cortisol axis in dialysis patients yields results suggesting Cushing's syndrome.

Original languageEnglish (US)
Pages (from-to)92-95
Number of pages4
JournalJournal of Clinical Endocrinology and Metabolism
Volume48
Issue number1
DOIs
StatePublished - Jan 1979

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

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    McDonald, W. J., Golper, T. A., Mass, R. D., Kendall, J. W., Porter, G. A., Girard, D. E., & Fischer, M. D. (1979). Adrenocorticotropin-cortisol axis abnormalities in hemodialysis patients. Journal of Clinical Endocrinology and Metabolism, 48(1), 92-95. https://doi.org/10.1210/jcem-48-1-92