Adrenocorticotropin-cortisol axis abnormalities in hemodialysis patients

Walter J. McDonald; Thomas A. Golper; Robert D. Mass; John W. Kendall; George A. Porter; Donald E. Girard; Mark D. Fischer

doi:10.1210/jcem-48-1-92

Adrenocorticotropin-cortisol axis abnormalities in hemodialysis patients

Walter J. McDonald, Thomas A. Golper, Robert D. Mass, John W. Kendall, George A. Porter, Donald E. Girard, Mark D. Fischer

Research output: Contribution to journal › Article › peer-review

65 Scopus citations

Abstract

The ACTH-cortisol axis was studied in 15 hemodialysis patients. Basal plasma cortisol concentrations were found to be elevated and ACTH to be in the high normal range. Cortisol responded normally to exogenous ACTH, but neither cortisol nor ACTH were suppressed in response to oral dexamethasone. 11-Deoxycortisol and ACTH concentrations did not rise normally in response to either oral or iv metyrapone. We conclude that standard testing of the ACTH-cortisol axis in dialysis patients yields results suggesting Cushing's syndrome.

Original language	English (US)
Pages (from-to)	92-95
Number of pages	4
Journal	Journal of Clinical Endocrinology and Metabolism
Volume	48
Issue number	1
DOIs	https://doi.org/10.1210/jcem-48-1-92
State	Published - Jan 1979
Externally published	Yes

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Biochemistry
Endocrinology
Clinical Biochemistry
Biochemistry, medical

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AU - Porter, George A.

AU - Girard, Donald E.

AU - Fischer, Mark D.

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N2 - The ACTH-cortisol axis was studied in 15 hemodialysis patients. Basal plasma cortisol concentrations were found to be elevated and ACTH to be in the high normal range. Cortisol responded normally to exogenous ACTH, but neither cortisol nor ACTH were suppressed in response to oral dexamethasone. 11-Deoxycortisol and ACTH concentrations did not rise normally in response to either oral or iv metyrapone. We conclude that standard testing of the ACTH-cortisol axis in dialysis patients yields results suggesting Cushing's syndrome.

AB - The ACTH-cortisol axis was studied in 15 hemodialysis patients. Basal plasma cortisol concentrations were found to be elevated and ACTH to be in the high normal range. Cortisol responded normally to exogenous ACTH, but neither cortisol nor ACTH were suppressed in response to oral dexamethasone. 11-Deoxycortisol and ACTH concentrations did not rise normally in response to either oral or iv metyrapone. We conclude that standard testing of the ACTH-cortisol axis in dialysis patients yields results suggesting Cushing's syndrome.

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Adrenocorticotropin-cortisol axis abnormalities in hemodialysis patients

Abstract

ASJC Scopus subject areas

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