Adrenocortical steroids modify neurotransmitter-stimulated cyclic AMP accumulation in the hippocampus and limbic brain of the rat

Allan Harrelson, W. Rostene, B. S. McEwen

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Glucocorticoid hormones are known to affect limbic system structures that have high levels of specific receptors for glucocorticoids, especially the hippocampus (HIPP). To understand how glucocorticoids may affect synaptic transmission, we have tested the effects of adrenal removal and glucocorticoid replacement on neurotransmitter-stimulated cyclic AMP accumulation in brain slices from the rat limbic system. Adrenalectomy (ADX) caused an enhancement of vasoactive intestinal peptide (VIP)-stimulated cyclic AMP accumulation in HIPP, amygdala (AMYG), and septum (SEP). In HIPP, ADX increased the cyclic AMP response to isoproterenol (ISOP) and decreased the response to histamine (HIST). In the AMYG and SEP, ADX did not affect significantly the action of ISOP, but ADX did decrease the response to HIST in AMYG. Administration of dexamethasone or corticosterone reversed the effects of ADX on cyclic AMP accumulation in the HIPP. The dexamethasone action on VIP-stimulated cyclic AMP accumulation takes place within 48 h and is most apparent in the mid-range of the VIP dose-response curve. These results demonstrate that glucocorticoids regulate neurotransmitter-stimulated cyclic AMP generation in a fashion that is specific, both for the neurotransmitter involved and for the brain regions affected.

Original languageEnglish (US)
Pages (from-to)1648-1655
Number of pages8
JournalJournal of Neurochemistry
Volume48
Issue number5
StatePublished - 1987
Externally publishedYes

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Cyclic AMP
Neurotransmitter Agents
Rats
Hippocampus
Brain
Steroids
Glucocorticoids
Vasoactive Intestinal Peptide
Amygdala
Limbic System
Isoproterenol
Histamine
Dexamethasone
Adrenalectomy
Glucocorticoid Receptors
Corticosterone
Synaptic Transmission
Hormones

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

Cite this

Adrenocortical steroids modify neurotransmitter-stimulated cyclic AMP accumulation in the hippocampus and limbic brain of the rat. / Harrelson, Allan; Rostene, W.; McEwen, B. S.

In: Journal of Neurochemistry, Vol. 48, No. 5, 1987, p. 1648-1655.

Research output: Contribution to journalArticle

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