Adrenocortical function in acquired immunodeficiency syndrome

L. Membreno, I. Irony, W. Dere, Robert Klein, E. G. Biglieri, E. Cobb

Research output: Contribution to journalArticle

172 Citations (Scopus)

Abstract

Clinical features of adrenal steroid deficiency occur in patients with the acquired immunodeficiency syndrome (AIDS). To determine the frequency of aberrations in peripheral steroid levels in patients with AIDS and AIDS-related complex (ARC) we measured morning recumbent plasma cortisol, deoxycorticosterone, 18-hydroxydeoxycorticosterone (18-OHDOC), corticosterone, aldosterone, and 18-hydroxycorticosterone concentrations before and after administration of 0.25 mg ACTH (Cosyntropin) in 74 randomly selected hospitalized patients with AIDS and 19 patients with ARC. Basal (0800 h) cortisol levels in the AIDS patients were significantly higher (P <0.01) than those in normal subjects, while other ACTH-dependent steroids of the 17-deoxypathway, deoxycorticosterone, corticosterone, and 18-OHDOC, were normal. These latter steroids increased subnormally in response to ACTH in patients with either AIDS (P <0.001) or ARC (P <0.005), but in ARC patients plasma 18-OHDOC levels were significantly higher than in those with AIDS (P <0.001). Supraphysiological doses of ACTH were then administered for 3 consecutive days to 14 patients with AIDS and 9 with ARC, which confirmed and amplified the subnormal responses of these steroids in AIDS. The mean plasma cortisol response was reduced on the third day only in AIDS patients, whereas in the ARC patients the steroid responses were normal. Angiotensin III infusion and postural stimulation increased plasma aldosterone and 18-hydroxycorticosterone levels in AIDS and ARC patients. Defective stimulation of 18-OHDOC alone or in combination with defective stimulation of other 17-deoxysteroids can be a harbinger of subsequent impaired adrenal capacity in AIDS.

Original languageEnglish (US)
Pages (from-to)482-487
Number of pages6
JournalJournal of Clinical Endocrinology and Metabolism
Volume65
Issue number3
StatePublished - 1987
Externally publishedYes

Fingerprint

Acquired Immunodeficiency Syndrome
Steroids
AIDS-Related Complex
Adrenocorticotropic Hormone
18-Hydroxycorticosterone
Plasmas
Hydrocortisone
Desoxycorticosterone
Corticosterone
Aldosterone
Angiotensin III
Cosyntropin
Aberrations

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

Membreno, L., Irony, I., Dere, W., Klein, R., Biglieri, E. G., & Cobb, E. (1987). Adrenocortical function in acquired immunodeficiency syndrome. Journal of Clinical Endocrinology and Metabolism, 65(3), 482-487.

Adrenocortical function in acquired immunodeficiency syndrome. / Membreno, L.; Irony, I.; Dere, W.; Klein, Robert; Biglieri, E. G.; Cobb, E.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 65, No. 3, 1987, p. 482-487.

Research output: Contribution to journalArticle

Membreno, L, Irony, I, Dere, W, Klein, R, Biglieri, EG & Cobb, E 1987, 'Adrenocortical function in acquired immunodeficiency syndrome', Journal of Clinical Endocrinology and Metabolism, vol. 65, no. 3, pp. 482-487.
Membreno, L. ; Irony, I. ; Dere, W. ; Klein, Robert ; Biglieri, E. G. ; Cobb, E. / Adrenocortical function in acquired immunodeficiency syndrome. In: Journal of Clinical Endocrinology and Metabolism. 1987 ; Vol. 65, No. 3. pp. 482-487.
@article{5ea99f6d1c9948c486c43559136d7b60,
title = "Adrenocortical function in acquired immunodeficiency syndrome",
abstract = "Clinical features of adrenal steroid deficiency occur in patients with the acquired immunodeficiency syndrome (AIDS). To determine the frequency of aberrations in peripheral steroid levels in patients with AIDS and AIDS-related complex (ARC) we measured morning recumbent plasma cortisol, deoxycorticosterone, 18-hydroxydeoxycorticosterone (18-OHDOC), corticosterone, aldosterone, and 18-hydroxycorticosterone concentrations before and after administration of 0.25 mg ACTH (Cosyntropin) in 74 randomly selected hospitalized patients with AIDS and 19 patients with ARC. Basal (0800 h) cortisol levels in the AIDS patients were significantly higher (P <0.01) than those in normal subjects, while other ACTH-dependent steroids of the 17-deoxypathway, deoxycorticosterone, corticosterone, and 18-OHDOC, were normal. These latter steroids increased subnormally in response to ACTH in patients with either AIDS (P <0.001) or ARC (P <0.005), but in ARC patients plasma 18-OHDOC levels were significantly higher than in those with AIDS (P <0.001). Supraphysiological doses of ACTH were then administered for 3 consecutive days to 14 patients with AIDS and 9 with ARC, which confirmed and amplified the subnormal responses of these steroids in AIDS. The mean plasma cortisol response was reduced on the third day only in AIDS patients, whereas in the ARC patients the steroid responses were normal. Angiotensin III infusion and postural stimulation increased plasma aldosterone and 18-hydroxycorticosterone levels in AIDS and ARC patients. Defective stimulation of 18-OHDOC alone or in combination with defective stimulation of other 17-deoxysteroids can be a harbinger of subsequent impaired adrenal capacity in AIDS.",
author = "L. Membreno and I. Irony and W. Dere and Robert Klein and Biglieri, {E. G.} and E. Cobb",
year = "1987",
language = "English (US)",
volume = "65",
pages = "482--487",
journal = "Journal of Clinical Endocrinology and Metabolism",
issn = "0021-972X",
publisher = "The Endocrine Society",
number = "3",

}

TY - JOUR

T1 - Adrenocortical function in acquired immunodeficiency syndrome

AU - Membreno, L.

AU - Irony, I.

AU - Dere, W.

AU - Klein, Robert

AU - Biglieri, E. G.

AU - Cobb, E.

PY - 1987

Y1 - 1987

N2 - Clinical features of adrenal steroid deficiency occur in patients with the acquired immunodeficiency syndrome (AIDS). To determine the frequency of aberrations in peripheral steroid levels in patients with AIDS and AIDS-related complex (ARC) we measured morning recumbent plasma cortisol, deoxycorticosterone, 18-hydroxydeoxycorticosterone (18-OHDOC), corticosterone, aldosterone, and 18-hydroxycorticosterone concentrations before and after administration of 0.25 mg ACTH (Cosyntropin) in 74 randomly selected hospitalized patients with AIDS and 19 patients with ARC. Basal (0800 h) cortisol levels in the AIDS patients were significantly higher (P <0.01) than those in normal subjects, while other ACTH-dependent steroids of the 17-deoxypathway, deoxycorticosterone, corticosterone, and 18-OHDOC, were normal. These latter steroids increased subnormally in response to ACTH in patients with either AIDS (P <0.001) or ARC (P <0.005), but in ARC patients plasma 18-OHDOC levels were significantly higher than in those with AIDS (P <0.001). Supraphysiological doses of ACTH were then administered for 3 consecutive days to 14 patients with AIDS and 9 with ARC, which confirmed and amplified the subnormal responses of these steroids in AIDS. The mean plasma cortisol response was reduced on the third day only in AIDS patients, whereas in the ARC patients the steroid responses were normal. Angiotensin III infusion and postural stimulation increased plasma aldosterone and 18-hydroxycorticosterone levels in AIDS and ARC patients. Defective stimulation of 18-OHDOC alone or in combination with defective stimulation of other 17-deoxysteroids can be a harbinger of subsequent impaired adrenal capacity in AIDS.

AB - Clinical features of adrenal steroid deficiency occur in patients with the acquired immunodeficiency syndrome (AIDS). To determine the frequency of aberrations in peripheral steroid levels in patients with AIDS and AIDS-related complex (ARC) we measured morning recumbent plasma cortisol, deoxycorticosterone, 18-hydroxydeoxycorticosterone (18-OHDOC), corticosterone, aldosterone, and 18-hydroxycorticosterone concentrations before and after administration of 0.25 mg ACTH (Cosyntropin) in 74 randomly selected hospitalized patients with AIDS and 19 patients with ARC. Basal (0800 h) cortisol levels in the AIDS patients were significantly higher (P <0.01) than those in normal subjects, while other ACTH-dependent steroids of the 17-deoxypathway, deoxycorticosterone, corticosterone, and 18-OHDOC, were normal. These latter steroids increased subnormally in response to ACTH in patients with either AIDS (P <0.001) or ARC (P <0.005), but in ARC patients plasma 18-OHDOC levels were significantly higher than in those with AIDS (P <0.001). Supraphysiological doses of ACTH were then administered for 3 consecutive days to 14 patients with AIDS and 9 with ARC, which confirmed and amplified the subnormal responses of these steroids in AIDS. The mean plasma cortisol response was reduced on the third day only in AIDS patients, whereas in the ARC patients the steroid responses were normal. Angiotensin III infusion and postural stimulation increased plasma aldosterone and 18-hydroxycorticosterone levels in AIDS and ARC patients. Defective stimulation of 18-OHDOC alone or in combination with defective stimulation of other 17-deoxysteroids can be a harbinger of subsequent impaired adrenal capacity in AIDS.

UR - http://www.scopus.com/inward/record.url?scp=0023212395&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023212395&partnerID=8YFLogxK

M3 - Article

C2 - 3040796

AN - SCOPUS:0023212395

VL - 65

SP - 482

EP - 487

JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

SN - 0021-972X

IS - 3

ER -