Adrenal venous sampling for primary aldosteronism and clinical outcomes after unilateral adrenalectomy: A single-center experience

Miho Murashima, Scott O. Trerotola, Douglas L. Fraker, Dale Han, Raymond R. Townsend, Debbie L. Cohen

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Adrenal venous sampling (AVS) remains controversial in the management of primary aldosteronism. Retrospective chart review was conducted at the Hospital of the University of Pennsylvania from July 2001 to September 2007. A total of 113 patients underwent AVS, 16 patients were excluded as records were unavailable. Among 97 remaining patients, 61 had unilateral disease and 57 underwent unilateral adrenalectomy. Blood pressure (BP) improved significantly with less antihypertensive medication requirement. Among those with different BP responses to adrenalectomy (cure, improvement, or no change), a higher number of preoperative antihypertensive medications was associated with persistent hypertension (P = .03). There were no significant differences in age (P = .14), duration of hypertension (P = .60), family history of hypertension (P = .68), or serum creatinine (P = .34). When AVS shows lateralization, age, duration of hypertension, family history, or renal dysfunction did not predict BP response to adrenalectomy. Results suggest that these factors should not preclude AVS and subsequent adrenalectomy. Further studies are indicated to confirm these findings.

Original languageEnglish (US)
Pages (from-to)316-323
Number of pages8
JournalJournal of Clinical Hypertension
Volume11
Issue number6
DOIs
StatePublished - Jun 1 2009
Externally publishedYes

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Hyperaldosteronism
Adrenalectomy
Hypertension
Blood Pressure
Antihypertensive Agents
Creatinine
Kidney
Serum

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Internal Medicine

Cite this

Adrenal venous sampling for primary aldosteronism and clinical outcomes after unilateral adrenalectomy : A single-center experience. / Murashima, Miho; Trerotola, Scott O.; Fraker, Douglas L.; Han, Dale; Townsend, Raymond R.; Cohen, Debbie L.

In: Journal of Clinical Hypertension, Vol. 11, No. 6, 01.06.2009, p. 316-323.

Research output: Contribution to journalArticle

Murashima, Miho ; Trerotola, Scott O. ; Fraker, Douglas L. ; Han, Dale ; Townsend, Raymond R. ; Cohen, Debbie L. / Adrenal venous sampling for primary aldosteronism and clinical outcomes after unilateral adrenalectomy : A single-center experience. In: Journal of Clinical Hypertension. 2009 ; Vol. 11, No. 6. pp. 316-323.
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