Adrenal function in women with idiopathic acne

G. P. Chrousos, G. L. Peck, E. G. Gross, G. B. Cutler, Donald (Lynn) Loriaux

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

The adrenal secretion of androgens was examined in 9 women (ages 19-39 yr) with postadolescent idiopathic acne and compared to age and sex-matched normal controls. Plasma dehydroepiandrosterone (DHA), dehydroepiandrosterone sulfate (DHAS), androstenedione (Δ4-A), cortisol, 17-hydroxyprogesterone, 11-deoxycortisol, and testosterone were measured by radioimmunoassay in the basal state and during a 48 hr ACTH infusion. The mean plasma and time-integrated plasma levels of the 3 adrenal androgens in patients with acne were 15-25% higher than normal controls, but the groups were not significantly different (p>.05). The plasma testosterone values, on the other hand, were similar in both groups. In addition, cortisol, 11-deoxycortisol and 17-hydroxyprogesterone basal plasma values and responses to ACTH in patients with acne were similar to the normal control values. These findings suggest that adrenal androgen secretion is at most mildly elevated in patients with idiopathic acne and is unlikely to be the sole cause of acne since many patients without acne have similar hormone levels. Increases sensitivity of the sebaceous gland to androgens or increased local metabolism of androgen hormones in the skin to potent androgen metabolites may offer alternative mechanisms for the pathogenesis of this disorder.

Original languageEnglish (US)
Pages (from-to)468-471
Number of pages4
JournalJournal of Investigative Dermatology
Volume78
Issue number6
DOIs
StatePublished - 1982
Externally publishedYes

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Acne Vulgaris
Androgens
Plasmas
Cortodoxone
17-alpha-Hydroxyprogesterone
Adrenocorticotropic Hormone
Hydrocortisone
Testosterone
Hormones
Sebaceous Glands
Dehydroepiandrosterone Sulfate
Dehydroepiandrosterone
Androstenedione
Metabolites
Metabolism
Radioimmunoassay
Skin
Reference Values
Control Groups

ASJC Scopus subject areas

  • Dermatology

Cite this

Adrenal function in women with idiopathic acne. / Chrousos, G. P.; Peck, G. L.; Gross, E. G.; Cutler, G. B.; Loriaux, Donald (Lynn).

In: Journal of Investigative Dermatology, Vol. 78, No. 6, 1982, p. 468-471.

Research output: Contribution to journalArticle

Chrousos, G. P. ; Peck, G. L. ; Gross, E. G. ; Cutler, G. B. ; Loriaux, Donald (Lynn). / Adrenal function in women with idiopathic acne. In: Journal of Investigative Dermatology. 1982 ; Vol. 78, No. 6. pp. 468-471.
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