Adolescent Binge Drinking Is Associated With Accelerated Decline of Gray Matter Volume

M. A. Infante; S. C. Eberson; Y. Zhang; T. Brumback; S. A. Brown; I. M. Colrain; F. C. Baker; D. B. Clark; M. D. De Bellis; D. Goldston; B. J. Nagel; K. B. Nooner; Q. Zhao; K. M. Pohl; E. V. Sullivan; A. Pfefferbaum; S. F. Tapert; W. K. Thompson

doi:10.1093/cercor/bhab368

Adolescent Binge Drinking Is Associated With Accelerated Decline of Gray Matter Volume

M. A. Infante, S. C. Eberson, Y. Zhang, T. Brumback, S. A. Brown, I. M. Colrain, F. C. Baker, D. B. Clark, M. D. De Bellis, D. Goldston, B. J. Nagel, K. B. Nooner, Q. Zhao, K. M. Pohl, E. V. Sullivan, A. Pfefferbaum, S. F. Tapert, W. K. Thompson

Psychiatry

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

The age- and time-dependent effects of binge drinking on adolescent brain development have not been well characterized even though binge drinking is a health crisis among adolescents. The impact of binge drinking on gray matter volume (GMV) development was examined using 5 waves of longitudinal data from the National Consortium on Alcohol and NeuroDevelopment in Adolescence study. Binge drinkers (n = 166) were compared with non-binge drinkers (n = 82 after matching on potential confounders). Number of binge drinking episodes in the past year was linked to decreased GMVs in bilateral Desikan-Killiany cortical parcellations (26 of 34 with P < 0.05/34) with the strongest effects observed in frontal regions. Interactions of binge drinking episodes and baseline age demonstrated stronger effects in younger participants. Statistical models sensitive to number of binge episodes and their temporal proximity to brain volumes provided the best fits. Consistent with prior research, results of this study highlight the negative effects of binge drinking on the developing brain. Our results present novel findings that cortical GMV decreases were greater in closer proximity to binge drinking episodes in a dose-response manner. This relation suggests a causal effect and raises the possibility that normal growth trajectories may be reinstated with alcohol abstinence.

Original language	English (US)
Pages (from-to)	2611-2620
Number of pages	10
Journal	Cerebral Cortex
Volume	32
Issue number	12
DOIs	https://doi.org/10.1093/cercor/bhab368
State	Published - Jun 15 2022

Keywords

adolescence
alcohol
binge drinking
brain development
cortical volume

ASJC Scopus subject areas

Cognitive Neuroscience
Cellular and Molecular Neuroscience

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10.1093/cercor/bhab368

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Infante, M. A., Eberson, S. C., Zhang, Y., Brumback, T., Brown, S. A., Colrain, I. M., Baker, F. C., Clark, D. B., De Bellis, M. D., Goldston, D., Nagel, B. J., Nooner, K. B., Zhao, Q., Pohl, K. M., Sullivan, E. V., Pfefferbaum, A., Tapert, S. F., & Thompson, W. K. (2022). Adolescent Binge Drinking Is Associated With Accelerated Decline of Gray Matter Volume. Cerebral Cortex, 32(12), 2611-2620. https://doi.org/10.1093/cercor/bhab368

Infante, MA, Eberson, SC, Zhang, Y, Brumback, T, Brown, SA, Colrain, IM, Baker, FC, Clark, DB, De Bellis, MD, Goldston, D, Nagel, BJ, Nooner, KB, Zhao, Q, Pohl, KM, Sullivan, EV, Pfefferbaum, A, Tapert, SF & Thompson, WK 2022, 'Adolescent Binge Drinking Is Associated With Accelerated Decline of Gray Matter Volume', Cerebral Cortex, vol. 32, no. 12, pp. 2611-2620. https://doi.org/10.1093/cercor/bhab368

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abstract = "The age- and time-dependent effects of binge drinking on adolescent brain development have not been well characterized even though binge drinking is a health crisis among adolescents. The impact of binge drinking on gray matter volume (GMV) development was examined using 5 waves of longitudinal data from the National Consortium on Alcohol and NeuroDevelopment in Adolescence study. Binge drinkers (n = 166) were compared with non-binge drinkers (n = 82 after matching on potential confounders). Number of binge drinking episodes in the past year was linked to decreased GMVs in bilateral Desikan-Killiany cortical parcellations (26 of 34 with P < 0.05/34) with the strongest effects observed in frontal regions. Interactions of binge drinking episodes and baseline age demonstrated stronger effects in younger participants. Statistical models sensitive to number of binge episodes and their temporal proximity to brain volumes provided the best fits. Consistent with prior research, results of this study highlight the negative effects of binge drinking on the developing brain. Our results present novel findings that cortical GMV decreases were greater in closer proximity to binge drinking episodes in a dose-response manner. This relation suggests a causal effect and raises the possibility that normal growth trajectories may be reinstated with alcohol abstinence.",

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AU - Brown, S. A.

AU - Colrain, I. M.

AU - Baker, F. C.

AU - Clark, D. B.

AU - De Bellis, M. D.

AU - Goldston, D.

AU - Nagel, B. J.

AU - Nooner, K. B.

AU - Zhao, Q.

AU - Pohl, K. M.

AU - Sullivan, E. V.

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AU - Thompson, W. K.

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Adolescent Binge Drinking Is Associated With Accelerated Decline of Gray Matter Volume

Abstract

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