TY - JOUR
T1 - Adjuncts to preparing wounds for closure Hyperbaric oxygen, growth factors, skin substitutes, negative pressure wound therapy (vacuum-assisted closure)
AU - Hopf, Harriet W.
AU - Humphrey, Lisa M.
AU - Puzziferri, Nancy
AU - West, Judith M.
AU - Attinger, Christopher E.
AU - Hunt, Thomas K.
N1 - Funding Information:
This work was supported by grant No. NIGMS 27345 from the National Institutes of Health.
PY - 2001/12
Y1 - 2001/12
N2 - Achieving closure in a chronic wound requires provision of adequate oxygen delivery to the tissue, adequate protein and other nutritional factors, a moist environment, an appropriate inflammatory milieu, dèbridement, and correction of contributing medical diagnoses. In some patients, these conditions are achieved easily, whereas in others, greater effort is required. Adjunctive treatments, including HBO2, growth factors, skin substitutes, and negative-pressure wound therapy (eg, V.A.C.) can provide the proper conditions for healing in appropriately selected patients.
AB - Achieving closure in a chronic wound requires provision of adequate oxygen delivery to the tissue, adequate protein and other nutritional factors, a moist environment, an appropriate inflammatory milieu, dèbridement, and correction of contributing medical diagnoses. In some patients, these conditions are achieved easily, whereas in others, greater effort is required. Adjunctive treatments, including HBO2, growth factors, skin substitutes, and negative-pressure wound therapy (eg, V.A.C.) can provide the proper conditions for healing in appropriately selected patients.
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U2 - 10.1016/S1083-7515(02)00008-6
DO - 10.1016/S1083-7515(02)00008-6
M3 - Review article
C2 - 12134577
AN - SCOPUS:0035554230
SN - 1083-7515
VL - 6
SP - 661
EP - 682
JO - Foot and Ankle Clinics
JF - Foot and Ankle Clinics
IS - 4
ER -