Adipose tissue NK cells manifest an activated phenotype in human obesity

Robert W. O'Rourke, Garen D. Gaston, Kevin A. Meyer, Ashley E. White, Daniel L. Marks

Research output: Contribution to journalArticle

33 Scopus citations

Abstract

Objective Adipose tissue inflammation is a cause of obesity-related metabolic disease. Natural killer (NK) cells are an understudied cell type in the context of obesity. The goal of this study was to determine the phenotype of human adipose tissue NK cells. Methods We used flow cytometry phenotyping to study adipose tissue and peripheral blood NK cells from obese and lean humans. Results Human adipose tissue NK cells, relative to peripheral blood NK cells, express increased levels of activation markers. Adipose tissue NK cells also demonstrate an activated phenotype in obese relative to lean subjects, with increased expression of the activating receptor NKG2D. Conclusions These data are the first detailed phenotypic characterization of human adipose tissue NK cells, and suggest a role for NK cells in adipose tissue inflammation in obesity.

Original languageEnglish (US)
Pages (from-to)1557-1561
Number of pages5
JournalMetabolism: Clinical and Experimental
Volume62
Issue number11
DOIs
StatePublished - Nov 2013

Keywords

  • CD56
  • Inflammation
  • NKG2D

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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