Adhesion molecules in radiotherapy

Roxana G. Baluna, Tony Y. Eng, Charles Thomas

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

Recent studies have documented changes in adhesion molecule expression and function after exposure to ionizing radiation. Adhesion molecules mediate cell-cell and cell-matrix interactions and are essential for a variety of physiological and pathological processes including maintenance of normal tissue integrity as well as tumor development and progression. Consequently, modulation of adhesion molecules by radiation may have a role in radiation-induced tumor control and normal tissue damage by interfering with cell signaling, radioresistance, metastasis, angiogenesis, carcinogenesis, immune response, inflammation and fibrosis. In addition, the interactions of radiation with adhesion molecules could have a major impact in developing new strategies to increase the efficacy of radiation therapy. Remarkable progress has been made in recent years to design targeted drug delivery to radiation-upregulated adhesion molecules. Furthermore, the inhibition of adhesion, migration, invasion and angiogenesis by blocking adhesion receptors may represent a new therapeutic approach to improve tumor control and decrease radiation toxicity. This review is focused on current data concerning the mechanistic interactions of radiation with adhesion molecules and the possible clinical-pathological implications in radiotherapy.

Original languageEnglish (US)
Pages (from-to)819-831
Number of pages13
JournalRadiation Research
Volume166
Issue number6
DOIs
StatePublished - Dec 2006

Fingerprint

radiotherapy
adhesion
radiation therapy
Radiotherapy
Radiation
molecules
radiation
angiogenesis
tumors
cells
Physiological Phenomena
neoplasms
Neoplasms
Drug Design
Cell Adhesion Molecules
Pathologic Processes
Ionizing Radiation
Cell Communication
fibrosis
radiation resistance

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Radiology Nuclear Medicine and imaging
  • Biophysics
  • Radiation

Cite this

Adhesion molecules in radiotherapy. / Baluna, Roxana G.; Eng, Tony Y.; Thomas, Charles.

In: Radiation Research, Vol. 166, No. 6, 12.2006, p. 819-831.

Research output: Contribution to journalArticle

Baluna, Roxana G. ; Eng, Tony Y. ; Thomas, Charles. / Adhesion molecules in radiotherapy. In: Radiation Research. 2006 ; Vol. 166, No. 6. pp. 819-831.
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