Adhesion GPCRs as novel actors in neural and glial cell functions: From synaptogenesis to myelination

Séverine M. Sigoillot, Kelly Monk, Xianhua Piao, Fekrije Selimi, Breanne L. Harty

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations

Abstract

Adhesion G-protein-coupled receptors (aGPCRs) are emerging as key regulators of nervous system development and health. aGPCRs can regulate many aspects of neural development, including cell signaling, cell-cell and cell-matrix interactions, and, potentially, mechanosensation. Here, we specifically focus on the roles of several aGPCRs in synapse biology, dendritogenesis, and myelinating glial cell development. The lessons learned from these examples may be extrapolated to other contexts in the nervous system and beyond.

Original languageEnglish (US)
Title of host publicationHandbook of Experimental Pharmacology
PublisherSpringer New York LLC
Pages275-298
Number of pages24
Volume234
DOIs
StatePublished - Nov 1 2016
Externally publishedYes

Publication series

NameHandbook of Experimental Pharmacology
Volume234
ISSN (Print)0171-2004
ISSN (Electronic)1865-0325

Keywords

  • Adhesion GPCR
  • Dendritogenesis
  • Myelination
  • Neurodevelopment
  • Synaptogenesis

ASJC Scopus subject areas

  • Biochemistry
  • Pharmacology, Toxicology and Pharmaceutics(all)

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  • Cite this

    Sigoillot, S. M., Monk, K., Piao, X., Selimi, F., & Harty, B. L. (2016). Adhesion GPCRs as novel actors in neural and glial cell functions: From synaptogenesis to myelination. In Handbook of Experimental Pharmacology (Vol. 234, pp. 275-298). (Handbook of Experimental Pharmacology; Vol. 234). Springer New York LLC. https://doi.org/10.1007/978-3-319-41523-9_12