Adhesion GPCRs as a putative class of metabotropic mechanosensors

Nicole Scholz, Kelly Monk, Robert J. Kittel, Tobias Langenhan

Research output: Chapter in Book/Report/Conference proceedingChapter

18 Citations (Scopus)

Abstract

G protein-coupled receptors (GPCRs) constitute the most versatile superfamily of biosensors. This group of receptors is formed by hundreds of GPCRs, each of which is tuned to the perception of a specific set of stimuli a cell may encounter emanating from the outside world or from internal sources. Most GPCRs are receptive for chemical compounds such as peptides, proteins, lipids, nucleotides, sugars, and other organic compounds, and this capacity is utilized in several sensory organs to initiate visual, olfactory, gustatory, or endocrine signals. In contrast, GPCRs have only anecdotally been implicated in the perception of mechanical stimuli. Recent studies, however, show that the family of adhesion GPCRs (aGPCRs), which represents a large panel of over 30 homologs within the GPCR superfamily, displays molecular design and expression patterns that are compatible with receptivity toward mechanical cues (Fig. 1). Here, we review physiological and molecular principles of established mechanosensors, discuss their relevance for current research of the mechanosensory function of aGPCRs, and survey the current state of knowledge on aGPCRs as mechanosensing molecules.

Original languageEnglish (US)
Title of host publicationHandbook of Experimental Pharmacology
PublisherSpringer New York LLC
Pages221-247
Number of pages27
Volume234
DOIs
StatePublished - Nov 1 2016
Externally publishedYes

Publication series

NameHandbook of Experimental Pharmacology
Volume234
ISSN (Print)0171-2004
ISSN (Electronic)1865-0325

Fingerprint

G-Protein-Coupled Receptors
Adhesion
Chemical compounds
Biosensing Techniques
Organic compounds
Biosensors
Sugars
Cues
Nucleotides
Lipids
Peptides
Molecules
Research
Proteins

Keywords

  • Adhesion GPCR
  • Mechanosensation
  • Mechanosensor

ASJC Scopus subject areas

  • Biochemistry
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Scholz, N., Monk, K., Kittel, R. J., & Langenhan, T. (2016). Adhesion GPCRs as a putative class of metabotropic mechanosensors. In Handbook of Experimental Pharmacology (Vol. 234, pp. 221-247). (Handbook of Experimental Pharmacology; Vol. 234). Springer New York LLC. https://doi.org/10.1007/978-3-319-41523-9_10

Adhesion GPCRs as a putative class of metabotropic mechanosensors. / Scholz, Nicole; Monk, Kelly; Kittel, Robert J.; Langenhan, Tobias.

Handbook of Experimental Pharmacology. Vol. 234 Springer New York LLC, 2016. p. 221-247 (Handbook of Experimental Pharmacology; Vol. 234).

Research output: Chapter in Book/Report/Conference proceedingChapter

Scholz, N, Monk, K, Kittel, RJ & Langenhan, T 2016, Adhesion GPCRs as a putative class of metabotropic mechanosensors. in Handbook of Experimental Pharmacology. vol. 234, Handbook of Experimental Pharmacology, vol. 234, Springer New York LLC, pp. 221-247. https://doi.org/10.1007/978-3-319-41523-9_10
Scholz N, Monk K, Kittel RJ, Langenhan T. Adhesion GPCRs as a putative class of metabotropic mechanosensors. In Handbook of Experimental Pharmacology. Vol. 234. Springer New York LLC. 2016. p. 221-247. (Handbook of Experimental Pharmacology). https://doi.org/10.1007/978-3-319-41523-9_10
Scholz, Nicole ; Monk, Kelly ; Kittel, Robert J. ; Langenhan, Tobias. / Adhesion GPCRs as a putative class of metabotropic mechanosensors. Handbook of Experimental Pharmacology. Vol. 234 Springer New York LLC, 2016. pp. 221-247 (Handbook of Experimental Pharmacology).
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