Adhesion G protein-coupled receptors in nervous system development and disease

Tobias Langenhan, Xianhua Piao, Kelly Monk

Research output: Contribution to journalReview articlepeer-review

63 Scopus citations


Members of the adhesion G protein-coupled receptor (aGPCR) class have emerged as crucial regulators of nervous system development, with important implications for human health and disease. In this Review, we discuss the current understanding of aGPCR functions during key steps in neural development, including cortical patterning, dendrite and synapse formation, and myelination. We focus on aGPCR modulation of cell-cell and cell-matrix interactions and signalling to control these varied aspects of neural development, and we discuss how impaired aGPCR function leads to neurological disease. We further highlight the emerging hypothesis that aGPCRs can be mechanically activated and the implications of this property in the nervous system.

Original languageEnglish (US)
Pages (from-to)550-561
Number of pages12
JournalNature Reviews Neuroscience
Issue number9
StatePublished - Sep 1 2016
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)


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