Adhesion G protein-coupled receptors: From in vitro pharmacology to in vivo mechanisms

Kelly R. Monk, Jörg Hamann, Tobias Langenhan, Saskia Nijmeijer, Torsten Schöneberg, Ines Liebscher

Research output: Contribution to journalArticle

28 Scopus citations

Abstract

The adhesion family of G protein-coupled receptors (aGPCRs) comprises 33 members in humans. aGPCRs are characterized by their enormous size and complex modular structures. While the physiologic importance of many aGPCRs has been clearly demonstrated in recent years, the underlying molecular functions have only recently begun to be elucidated. In this minireview, we present an overview of our current knowledge on aGPCR activation and signal transduction with a focus on the latest findings regarding the interplay between ligand binding, mechanical force, and the tethered agonistic Stachel sequence, as well as implications on translational approaches that may derive from understanding aGPCR pharmacology.

Original languageEnglish (US)
Pages (from-to)617-623
Number of pages7
JournalMolecular pharmacology
Volume88
Issue number3
DOIs
StatePublished - Sep 1 2015

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology

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    Monk, K. R., Hamann, J., Langenhan, T., Nijmeijer, S., Schöneberg, T., & Liebscher, I. (2015). Adhesion G protein-coupled receptors: From in vitro pharmacology to in vivo mechanisms. Molecular pharmacology, 88(3), 617-623. https://doi.org/10.1124/mol.115.098749