TY - JOUR
T1 - Adhesion G protein-coupled receptors
T2 - From in vitro pharmacology to in vivo mechanisms
AU - Monk, Kelly R.
AU - Hamann, Jörg
AU - Langenhan, Tobias
AU - Nijmeijer, Saskia
AU - Schöneberg, Torsten
AU - Liebscher, Ines
N1 - Publisher Copyright:
Copyright © 2015 by The American Society for Pharmacology and Experimental Therapeutics.
PY - 2015/9/1
Y1 - 2015/9/1
N2 - The adhesion family of G protein-coupled receptors (aGPCRs) comprises 33 members in humans. aGPCRs are characterized by their enormous size and complex modular structures. While the physiologic importance of many aGPCRs has been clearly demonstrated in recent years, the underlying molecular functions have only recently begun to be elucidated. In this minireview, we present an overview of our current knowledge on aGPCR activation and signal transduction with a focus on the latest findings regarding the interplay between ligand binding, mechanical force, and the tethered agonistic Stachel sequence, as well as implications on translational approaches that may derive from understanding aGPCR pharmacology.
AB - The adhesion family of G protein-coupled receptors (aGPCRs) comprises 33 members in humans. aGPCRs are characterized by their enormous size and complex modular structures. While the physiologic importance of many aGPCRs has been clearly demonstrated in recent years, the underlying molecular functions have only recently begun to be elucidated. In this minireview, we present an overview of our current knowledge on aGPCR activation and signal transduction with a focus on the latest findings regarding the interplay between ligand binding, mechanical force, and the tethered agonistic Stachel sequence, as well as implications on translational approaches that may derive from understanding aGPCR pharmacology.
UR - http://www.scopus.com/inward/record.url?scp=84939800716&partnerID=8YFLogxK
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U2 - 10.1124/mol.115.098749
DO - 10.1124/mol.115.098749
M3 - Article
C2 - 25956432
AN - SCOPUS:84939800716
SN - 0026-895X
VL - 88
SP - 617
EP - 623
JO - Molecular pharmacology
JF - Molecular pharmacology
IS - 3
ER -