Adherence to HIV antiretroviral therapy in HIV+ Ugandan patients purchasing therapy

Jayne Byakika-Tusiime, J. H. Oyugi, W. A. Tumwikirize, E. T. Katabira, P. N. Mugyenyi, David Bangsberg

Research output: Contribution to journalArticle

126 Citations (Scopus)

Abstract

Our objective was to determine the level of adherence and reasons for non-adherence to antiretroviral therapy (ART) among HIV-positive (HIV+) people on ART in a resource-limited setting. Patients receiving ART were recruited into the cross-sectional study from three treatment centres in Kampala, Uganda. The number of missed doses over the last three days was assessed by structured patient interviews and dichotomized at ±95% adherence. Reasons for non-adherence were assessed with both structured patient interviews and unstructured qualitative interviews. Independent predictors of non-adherence were assessed with multivariate logistic regression. In all, 304 HIV-infected persons on ART were enrolled into the study. Factors associated with non-adherence were marital status (odds ratio (OR) = 2.93, 95% confidence interval (CI) 1.32-6.50) and low monthly income <50 US$ [OR = 2.77, 95% CI 1.64-4.67]. We concluded that levels of self-reported adherence in patients receiving ART in Kampala are comparable to levels in resource-rich settings with inability to purchase and secure a stable supply as a major barrier to adherence.

Original languageEnglish (US)
Pages (from-to)38-41
Number of pages4
JournalInternational Journal of STD and AIDS
Volume16
Issue number1
DOIs
StatePublished - Jan 2005
Externally publishedYes

Fingerprint

HIV
Interviews
Therapeutics
Odds Ratio
Confidence Intervals
Uganda
Marital Status
Patient Compliance
Cross-Sectional Studies
Logistic Models

Keywords

  • Adherence
  • Antiretroviral therapy
  • Self-purchasing
  • Sub-Saharan Africa

ASJC Scopus subject areas

  • Dermatology
  • Public Health, Environmental and Occupational Health
  • Pharmacology (medical)
  • Infectious Diseases

Cite this

Adherence to HIV antiretroviral therapy in HIV+ Ugandan patients purchasing therapy. / Byakika-Tusiime, Jayne; Oyugi, J. H.; Tumwikirize, W. A.; Katabira, E. T.; Mugyenyi, P. N.; Bangsberg, David.

In: International Journal of STD and AIDS, Vol. 16, No. 1, 01.2005, p. 38-41.

Research output: Contribution to journalArticle

Byakika-Tusiime, Jayne ; Oyugi, J. H. ; Tumwikirize, W. A. ; Katabira, E. T. ; Mugyenyi, P. N. ; Bangsberg, David. / Adherence to HIV antiretroviral therapy in HIV+ Ugandan patients purchasing therapy. In: International Journal of STD and AIDS. 2005 ; Vol. 16, No. 1. pp. 38-41.
@article{1cc1da08838041b9afa4ec60e4c28c04,
title = "Adherence to HIV antiretroviral therapy in HIV+ Ugandan patients purchasing therapy",
abstract = "Our objective was to determine the level of adherence and reasons for non-adherence to antiretroviral therapy (ART) among HIV-positive (HIV+) people on ART in a resource-limited setting. Patients receiving ART were recruited into the cross-sectional study from three treatment centres in Kampala, Uganda. The number of missed doses over the last three days was assessed by structured patient interviews and dichotomized at ±95{\%} adherence. Reasons for non-adherence were assessed with both structured patient interviews and unstructured qualitative interviews. Independent predictors of non-adherence were assessed with multivariate logistic regression. In all, 304 HIV-infected persons on ART were enrolled into the study. Factors associated with non-adherence were marital status (odds ratio (OR) = 2.93, 95{\%} confidence interval (CI) 1.32-6.50) and low monthly income <50 US$ [OR = 2.77, 95{\%} CI 1.64-4.67]. We concluded that levels of self-reported adherence in patients receiving ART in Kampala are comparable to levels in resource-rich settings with inability to purchase and secure a stable supply as a major barrier to adherence.",
keywords = "Adherence, Antiretroviral therapy, Self-purchasing, Sub-Saharan Africa",
author = "Jayne Byakika-Tusiime and Oyugi, {J. H.} and Tumwikirize, {W. A.} and Katabira, {E. T.} and Mugyenyi, {P. N.} and David Bangsberg",
year = "2005",
month = "1",
doi = "10.1258/0956462052932548",
language = "English (US)",
volume = "16",
pages = "38--41",
journal = "International Journal of STD and AIDS",
issn = "0956-4624",
publisher = "SAGE Publications Ltd",
number = "1",

}

TY - JOUR

T1 - Adherence to HIV antiretroviral therapy in HIV+ Ugandan patients purchasing therapy

AU - Byakika-Tusiime, Jayne

AU - Oyugi, J. H.

AU - Tumwikirize, W. A.

AU - Katabira, E. T.

AU - Mugyenyi, P. N.

AU - Bangsberg, David

PY - 2005/1

Y1 - 2005/1

N2 - Our objective was to determine the level of adherence and reasons for non-adherence to antiretroviral therapy (ART) among HIV-positive (HIV+) people on ART in a resource-limited setting. Patients receiving ART were recruited into the cross-sectional study from three treatment centres in Kampala, Uganda. The number of missed doses over the last three days was assessed by structured patient interviews and dichotomized at ±95% adherence. Reasons for non-adherence were assessed with both structured patient interviews and unstructured qualitative interviews. Independent predictors of non-adherence were assessed with multivariate logistic regression. In all, 304 HIV-infected persons on ART were enrolled into the study. Factors associated with non-adherence were marital status (odds ratio (OR) = 2.93, 95% confidence interval (CI) 1.32-6.50) and low monthly income <50 US$ [OR = 2.77, 95% CI 1.64-4.67]. We concluded that levels of self-reported adherence in patients receiving ART in Kampala are comparable to levels in resource-rich settings with inability to purchase and secure a stable supply as a major barrier to adherence.

AB - Our objective was to determine the level of adherence and reasons for non-adherence to antiretroviral therapy (ART) among HIV-positive (HIV+) people on ART in a resource-limited setting. Patients receiving ART were recruited into the cross-sectional study from three treatment centres in Kampala, Uganda. The number of missed doses over the last three days was assessed by structured patient interviews and dichotomized at ±95% adherence. Reasons for non-adherence were assessed with both structured patient interviews and unstructured qualitative interviews. Independent predictors of non-adherence were assessed with multivariate logistic regression. In all, 304 HIV-infected persons on ART were enrolled into the study. Factors associated with non-adherence were marital status (odds ratio (OR) = 2.93, 95% confidence interval (CI) 1.32-6.50) and low monthly income <50 US$ [OR = 2.77, 95% CI 1.64-4.67]. We concluded that levels of self-reported adherence in patients receiving ART in Kampala are comparable to levels in resource-rich settings with inability to purchase and secure a stable supply as a major barrier to adherence.

KW - Adherence

KW - Antiretroviral therapy

KW - Self-purchasing

KW - Sub-Saharan Africa

UR - http://www.scopus.com/inward/record.url?scp=13244263044&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=13244263044&partnerID=8YFLogxK

U2 - 10.1258/0956462052932548

DO - 10.1258/0956462052932548

M3 - Article

C2 - 15705271

AN - SCOPUS:13244263044

VL - 16

SP - 38

EP - 41

JO - International Journal of STD and AIDS

JF - International Journal of STD and AIDS

SN - 0956-4624

IS - 1

ER -