Adherence to antiretroviral therapy among HIV-infected methadone patients: Effect of ongoing illicit drug use

Michael D. Stein, Josiah D. Rich, Jina Maksad, Mei Hsiu Chen, Ping Hu, Mindy Sobota, Jennifer Clarke

Research output: Contribution to journalArticle

85 Scopus citations

Abstract

Methadone maintenance patients infected with human immunodeficiency virus (HIV) currently receiving antiretroviral therapy had HIV RNA testing and were surveyed regarding their adherence to their treatment regimens. Adherence was measured using self-report on four questions relating to medication use in the last day and last month and whether the patient took 'drug holidays.' Of the patients (N = 42), 52% were receiving two-drug antiretroviral therapy and 48% were receiving triple therapy that included a protease inhibitor. Persons on triple therapy reported higher rates of adherence on all measures and were more likely to have undetectable HIV RNA levels than persons on dual therapy (60% vs. 50%). Ongoing illicit drug injection was the only factor significantly associated (p < .05) with multiple measure nonadherence; however, it was not associated with undetectable HIV RNA level. Levels of nonadherence were comparable to estimates from other chronic diseases, but this finding has important implications for patients receiving highly active antiretroviral therapy.

Original languageEnglish (US)
Pages (from-to)195-205
Number of pages11
JournalAmerican Journal of Drug and Alcohol Abuse
Volume26
Issue number2
DOIs
StatePublished - Jun 27 2000

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Clinical Psychology
  • Psychiatry and Mental health

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