Adherence is not a barrier to successful antiretroviral therapy in South Africa

Catherine Orrell, David Bangsberg, Motasim Badri, Robin Wood

Research output: Contribution to journalArticle

245 Citations (Scopus)

Abstract

Objective: to determine adherence of an indigent African HIV-infected cohort initiating antiretroviral therapy (ART); to identify predictors of incomplete adherence (< 95%) and virologic failure (> 400 HIV RNA copies/ml). Design: Prospective monitoring of adherence in a poor HIV-positive cohort, attending a public sector hospital and receiving ART through phase III studies. Methods: Adherence to ART was determined over 48 weeks by counting tablet-returns. Logistic regression models including age, WHO HIV stage, home language, socio-economic status, complexity and type of regimen were fitted to determine predictors of incomplete adherence and virologic failure at 48 weeks. Results: 289 patients were recruited between January 1996 and May 2001. Median (mean) adherence of the cohort was 93.5% (87.2%). Three times daily dosing [risk ratio (RR), 3.07; 95% confidence interval (CI), 1.40-6.74], speaking English (RR, 0.41; 95% CI, 0.21-0.80) and age (RR, 0.97; 95% CI, 0.94-0.99) were independent predictors of incomplete adherence. Socio-economic status, sex and HIV stage did not predict adherence. Independent predictors of virologic failure included baseline viral load (RR, 2.57; 95% CI, 1.57-4.22) and three times daily dosing (RR, 2.64; 95% CI, 1.23-5.66), incomplete adherence (RR, 1.92; 95% CI, 1.10-3.57), age (RR, 0.96; 95% CI, 0.92-0.99) and dual nucleoside therapy (RR, 2.69; 95% CI, 1.1 7-6.15). Conclusion: The proportion of individuals achieving viral suppression matched results from the developing world. Speaking the same language as site staff and simplified dosing frequency were beneficial. Socio-economic status had no impact on adherence and should not be used as a limitation to ART access.

Original languageEnglish (US)
Pages (from-to)1369-1375
Number of pages7
JournalAIDS
Volume17
Issue number9
DOIs
StatePublished - Jun 13 2003
Externally publishedYes

Fingerprint

South Africa
Odds Ratio
Confidence Intervals
HIV
Economics
Therapeutics
Language
Logistic Models
Public Sector
Public Hospitals
Poverty
Viral Load
Nucleosides
Tablets
RNA

Keywords

  • Adherence
  • Africa
  • Antiretroviral therapy
  • Socio-economic status
  • Viral load

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

Cite this

Adherence is not a barrier to successful antiretroviral therapy in South Africa. / Orrell, Catherine; Bangsberg, David; Badri, Motasim; Wood, Robin.

In: AIDS, Vol. 17, No. 9, 13.06.2003, p. 1369-1375.

Research output: Contribution to journalArticle

Orrell, Catherine ; Bangsberg, David ; Badri, Motasim ; Wood, Robin. / Adherence is not a barrier to successful antiretroviral therapy in South Africa. In: AIDS. 2003 ; Vol. 17, No. 9. pp. 1369-1375.
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abstract = "Objective: to determine adherence of an indigent African HIV-infected cohort initiating antiretroviral therapy (ART); to identify predictors of incomplete adherence (< 95{\%}) and virologic failure (> 400 HIV RNA copies/ml). Design: Prospective monitoring of adherence in a poor HIV-positive cohort, attending a public sector hospital and receiving ART through phase III studies. Methods: Adherence to ART was determined over 48 weeks by counting tablet-returns. Logistic regression models including age, WHO HIV stage, home language, socio-economic status, complexity and type of regimen were fitted to determine predictors of incomplete adherence and virologic failure at 48 weeks. Results: 289 patients were recruited between January 1996 and May 2001. Median (mean) adherence of the cohort was 93.5{\%} (87.2{\%}). Three times daily dosing [risk ratio (RR), 3.07; 95{\%} confidence interval (CI), 1.40-6.74], speaking English (RR, 0.41; 95{\%} CI, 0.21-0.80) and age (RR, 0.97; 95{\%} CI, 0.94-0.99) were independent predictors of incomplete adherence. Socio-economic status, sex and HIV stage did not predict adherence. Independent predictors of virologic failure included baseline viral load (RR, 2.57; 95{\%} CI, 1.57-4.22) and three times daily dosing (RR, 2.64; 95{\%} CI, 1.23-5.66), incomplete adherence (RR, 1.92; 95{\%} CI, 1.10-3.57), age (RR, 0.96; 95{\%} CI, 0.92-0.99) and dual nucleoside therapy (RR, 2.69; 95{\%} CI, 1.1 7-6.15). Conclusion: The proportion of individuals achieving viral suppression matched results from the developing world. Speaking the same language as site staff and simplified dosing frequency were beneficial. Socio-economic status had no impact on adherence and should not be used as a limitation to ART access.",
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AB - Objective: to determine adherence of an indigent African HIV-infected cohort initiating antiretroviral therapy (ART); to identify predictors of incomplete adherence (< 95%) and virologic failure (> 400 HIV RNA copies/ml). Design: Prospective monitoring of adherence in a poor HIV-positive cohort, attending a public sector hospital and receiving ART through phase III studies. Methods: Adherence to ART was determined over 48 weeks by counting tablet-returns. Logistic regression models including age, WHO HIV stage, home language, socio-economic status, complexity and type of regimen were fitted to determine predictors of incomplete adherence and virologic failure at 48 weeks. Results: 289 patients were recruited between January 1996 and May 2001. Median (mean) adherence of the cohort was 93.5% (87.2%). Three times daily dosing [risk ratio (RR), 3.07; 95% confidence interval (CI), 1.40-6.74], speaking English (RR, 0.41; 95% CI, 0.21-0.80) and age (RR, 0.97; 95% CI, 0.94-0.99) were independent predictors of incomplete adherence. Socio-economic status, sex and HIV stage did not predict adherence. Independent predictors of virologic failure included baseline viral load (RR, 2.57; 95% CI, 1.57-4.22) and three times daily dosing (RR, 2.64; 95% CI, 1.23-5.66), incomplete adherence (RR, 1.92; 95% CI, 1.10-3.57), age (RR, 0.96; 95% CI, 0.92-0.99) and dual nucleoside therapy (RR, 2.69; 95% CI, 1.1 7-6.15). Conclusion: The proportion of individuals achieving viral suppression matched results from the developing world. Speaking the same language as site staff and simplified dosing frequency were beneficial. Socio-economic status had no impact on adherence and should not be used as a limitation to ART access.

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