Adenovirus infections in adult recipients of blood and marrow transplants

A. M. La Rosa, R. E. Champlin, N. Mirza, J. Gajewski, S. Giralt, K. V. Rolston, I. Raad, K. Jacobson, D. Kontoyiannis, L. Elting, E. Whimbey

Research output: Contribution to journalArticle

224 Citations (Scopus)

Abstract

Adenoviruses are increasingly recognized pathogens that affect blood and marrow transplant (BMT) recipients. Experiences with 2889 adult BMT recipients were reviewed to study the incidence, clinical spectrum, risk factors for dissemination, response to therapy, and outcome of adenovirus infections. Eight-five patients (3%) were diagnosed by means of culture (n = 85) or culture and histopathological examination (n = 6). Nine patients had asymptomatic viruria, and 76 had symptomatic infections, which included upper respiratory tract infection (n = 20), enteritis (n = 18), hemorrhagic cystitis (n = 10), pneumonia (n = 15), and disseminated disease (n = 13). The overall mortality rate was 26%. A higher mortality rate was observed among patients with pneumonia (73%) and disseminated disease (61%). Risk factors for dissemination included receipt of an allogeneic transplant, presence of graft-versus-host disease (GVHD), and receipt of concurrent immunosuppressive therapy. Intravenous ribavirin was not associated with an appreciable benefit among 12 patients who received this treatment. In conclusion, adenovirus infections are an important cause of morbidity and mortality in adult BMT recipients, particularly allogeneic transplant recipients with GVHD who are receiving immunosuppressive therapy. The need for an effective, nontoxic antiviral therapy is apparent.

Original languageEnglish (US)
Pages (from-to)871-876
Number of pages6
JournalClinical Infectious Diseases
Volume32
Issue number6
DOIs
StatePublished - Mar 15 2001
Externally publishedYes

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Adenoviridae Infections
Bone Marrow
Transplants
Graft vs Host Disease
Immunosuppressive Agents
Mortality
Pneumonia
Therapeutics
Cystitis
Enteritis
Ribavirin
Adenoviridae
Respiratory Tract Infections
Antiviral Agents
Cohort Studies
Morbidity
Transplant Recipients
Infection

ASJC Scopus subject areas

  • Immunology

Cite this

La Rosa, A. M., Champlin, R. E., Mirza, N., Gajewski, J., Giralt, S., Rolston, K. V., ... Whimbey, E. (2001). Adenovirus infections in adult recipients of blood and marrow transplants. Clinical Infectious Diseases, 32(6), 871-876. https://doi.org/10.1086/319352

Adenovirus infections in adult recipients of blood and marrow transplants. / La Rosa, A. M.; Champlin, R. E.; Mirza, N.; Gajewski, J.; Giralt, S.; Rolston, K. V.; Raad, I.; Jacobson, K.; Kontoyiannis, D.; Elting, L.; Whimbey, E.

In: Clinical Infectious Diseases, Vol. 32, No. 6, 15.03.2001, p. 871-876.

Research output: Contribution to journalArticle

La Rosa, AM, Champlin, RE, Mirza, N, Gajewski, J, Giralt, S, Rolston, KV, Raad, I, Jacobson, K, Kontoyiannis, D, Elting, L & Whimbey, E 2001, 'Adenovirus infections in adult recipients of blood and marrow transplants', Clinical Infectious Diseases, vol. 32, no. 6, pp. 871-876. https://doi.org/10.1086/319352
La Rosa AM, Champlin RE, Mirza N, Gajewski J, Giralt S, Rolston KV et al. Adenovirus infections in adult recipients of blood and marrow transplants. Clinical Infectious Diseases. 2001 Mar 15;32(6):871-876. https://doi.org/10.1086/319352
La Rosa, A. M. ; Champlin, R. E. ; Mirza, N. ; Gajewski, J. ; Giralt, S. ; Rolston, K. V. ; Raad, I. ; Jacobson, K. ; Kontoyiannis, D. ; Elting, L. ; Whimbey, E. / Adenovirus infections in adult recipients of blood and marrow transplants. In: Clinical Infectious Diseases. 2001 ; Vol. 32, No. 6. pp. 871-876.
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