Abstract
Nef-specific CD8+ T lymphocytes (CD8TL) are associated with control of simian immunodeficiency virus (SIV) despite extensive nef variation between and within animals. Deep viral sequencing of the immunodominant Mamu-B*017:01-restricted Nef165-173IW9 epitope revealed highly restricted evolution. A common acute escape variant, T170I, unexpectedly and uniquely degraded Nef-s major histocompatibility complex class I (MHC-I) downregulatory capacity, rendering the virus more vulnerable to CD8TL targeting other epitopes. These data aid in a mechanistic understanding of Nef functions and suggest means of immunity-mediated control of lentivirus replication.
Original language | English (US) |
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Pages (from-to) | 2119-2126 |
Number of pages | 8 |
Journal | Journal of virology |
Volume | 90 |
Issue number | 4 |
DOIs | |
State | Published - 2016 |
ASJC Scopus subject areas
- Microbiology
- Immunology
- Insect Science
- Virology