@article{d9770a4811bf49a5bff8d15d9bb6b940,
title = "Acute viral escape selectively impairs nef-mediated major histocompatibility complex class i downmodulation and increases susceptibility to antiviral t cells",
abstract = "Nef-specific CD8+ T lymphocytes (CD8TL) are associated with control of simian immunodeficiency virus (SIV) despite extensive nef variation between and within animals. Deep viral sequencing of the immunodominant Mamu-B*017:01-restricted Nef165-173IW9 epitope revealed highly restricted evolution. A common acute escape variant, T170I, unexpectedly and uniquely degraded Nef-s major histocompatibility complex class I (MHC-I) downregulatory capacity, rendering the virus more vulnerable to CD8TL targeting other epitopes. These data aid in a mechanistic understanding of Nef functions and suggest means of immunity-mediated control of lentivirus replication.",
author = "Weiler, {Andrea M.} and Arpita Das and Oluwasayo Akinyosoye and Sherry Cui and O'Connor, {Shelby L.} and Scheef, {Elizabeth A.} and Reed, {Jason S.} and Panganiban, {Antonito T.} and Sacha, {Jonah B.} and Rakasz, {Eva G.} and Friedrich, {Thomas C.} and Maness, {Nicholas J.}",
note = "Funding Information: This work was supported by NIH grants OD011106 and OD011104 (base grants to the Wisconsin and Tulane National Primate Research Centers, respectively) and by AI 112447 to N.J.M. and AI 084787 to T.C.F. The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication. Publisher Copyright: {\textcopyright} 2016, American Society for Microbiology.",
year = "2016",
doi = "10.1128/JVI.01975-15",
language = "English (US)",
volume = "90",
pages = "2119--2126",
journal = "Journal of Virology",
issn = "0022-538X",
publisher = "American Society for Microbiology",
number = "4",
}