Acute Tumor Lysis Syndrome with Choriocarcinoma

Charles Blanke, Maj Paul A Hemmer, Robert S. Witte

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

A 52-year-old man with retroperitoneal nodal, lung, and liver metastases from choriocarcinoma received chemotherapy with etoposide, cisplatin, and bleomycin. Within 48 hours of starting treatment, he had hypotension, hypoxemia, and anuria. Laboratory values showed hyperuricemia, hyperkalemia, hyperphosphatemia, hypocalcemia, and metabolic acidosis. He was placed on mechanical ventilation, and hemodialysis was instituted, with marked improvement in renal function. A second, shortened course of chemotherapy with carboplatin and etoposide was given 21 days later. However, on hospital day 48, the patient died of progressive pulmonary insufficiency and cardiac arrest. This represents the first reported case of acute tumor lysis syndrome after systemic chemotherapy for advanced nonseminomatous germ cell cancer.

Original languageEnglish (US)
Pages (from-to)916-919
Number of pages4
JournalSouthern Medical Journal
Volume93
Issue number9
StatePublished - Sep 2000

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Tumor Lysis Syndrome
Choriocarcinoma
Etoposide
Drug Therapy
Hyperphosphatemia
Anuria
Lung
Hyperuricemia
Hyperkalemia
Hypocalcemia
Germ Cell and Embryonal Neoplasms
Carboplatin
Bleomycin
Acidosis
Heart Arrest
Artificial Respiration
Hypotension
Cisplatin
Renal Dialysis
Neoplasm Metastasis

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Blanke, C., Hemmer, M. P. A., & Witte, R. S. (2000). Acute Tumor Lysis Syndrome with Choriocarcinoma. Southern Medical Journal, 93(9), 916-919.

Acute Tumor Lysis Syndrome with Choriocarcinoma. / Blanke, Charles; Hemmer, Maj Paul A; Witte, Robert S.

In: Southern Medical Journal, Vol. 93, No. 9, 09.2000, p. 916-919.

Research output: Contribution to journalArticle

Blanke, C, Hemmer, MPA & Witte, RS 2000, 'Acute Tumor Lysis Syndrome with Choriocarcinoma', Southern Medical Journal, vol. 93, no. 9, pp. 916-919.
Blanke, Charles ; Hemmer, Maj Paul A ; Witte, Robert S. / Acute Tumor Lysis Syndrome with Choriocarcinoma. In: Southern Medical Journal. 2000 ; Vol. 93, No. 9. pp. 916-919.
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