Acute stress evokes selective mobilization of T cells that differ in chemokine receptor expression: A potential pathway linking immunologic reactivity to cardiovascular disease

Jos A. Bosch, Gary G. Berntson, John T. Cacioppo, Firdaus S. Dhabhar, Phillip Marucha

Research output: Contribution to journalArticle

83 Citations (Scopus)

Abstract

T lymphocytes and monocytes/macrophages are the most abundant cells found in the atherosclerotic plaque. These cells can migrate towards the activated endothelium through the local release of chemotactic cytokines, or chemokines. Given the important role of leukocyte migration in atherosclerosis and the role of stress in mediating leukocyte trafficking, the present study examined the effects of an acute stressor on the redistribution of T cells (CD3+) and monocytes that express the chemokine receptors CCR5, CCR6, CXCR1, CXCR2, CXCR3, and CXCR4. Forty-four undergraduate students underwent a public speaking task. The acute stressor induced sympathetic cardiac activation, parasympathetic cardiac withdrawal, lymphocytosis, and monocytosis (all p

Original languageEnglish (US)
Pages (from-to)251-259
Number of pages9
JournalBrain, Behavior, and Immunity
Volume17
Issue number4
DOIs
StatePublished - Aug 2003
Externally publishedYes

Fingerprint

Chemokine Receptors
Chemokines
Monocytes
Leukocytes
Cardiovascular Diseases
T-Lymphocytes
Lymphocytosis
Atherosclerotic Plaques
Endothelium
Atherosclerosis
Macrophages
Students

Keywords

  • Acute psychological stressor
  • Autonomic balance
  • Cardiovascular disease
  • Cardiovascular reactivity
  • Chemokines
  • Lymphocyte redistribution
  • Psychoneuroimmunology

ASJC Scopus subject areas

  • Immunology
  • Behavioral Neuroscience
  • Endocrine and Autonomic Systems

Cite this

Acute stress evokes selective mobilization of T cells that differ in chemokine receptor expression : A potential pathway linking immunologic reactivity to cardiovascular disease. / Bosch, Jos A.; Berntson, Gary G.; Cacioppo, John T.; Dhabhar, Firdaus S.; Marucha, Phillip.

In: Brain, Behavior, and Immunity, Vol. 17, No. 4, 08.2003, p. 251-259.

Research output: Contribution to journalArticle

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