Acute retinal necrosis secondary to multidrug-resistant herpes simplex virus 2 in an immunocompetent adolescent

Adrian T. Dokey, Sara J. Haug, H. Richard McDonald, Emmett T. Cunningham, Brandon Lujan, Arthur D. Fu, J. Michael Jumper

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Purpose: To report the clinical course of a patient with acute retinal necrosis resulting from a multidrug-resistant strain of herpes simplex virus 2. Methods: Observational case report. Results: A 17-year-old man with no identifiable immune deficiency presented with pain and decreased vision in his left eye. He had dense anterior and posterior segment inflammation with retinal whitening suggestive of acute retinal necrosis, which progressed despite treatment with intravenous acyclovir, methylprednisolone, and ganciclovir. A transition to intravitreal and intravenous foscarnet led to clinical improvement. Genetic analysis revealed the etiology to be a multidrug-resistant strain of herpes simplex virus 2. Conclusion: Antiviral resistance is an uncommon finding among viruses causing acute retinal necrosis in immunocompetent patients. Patients with these infections may be adequately treated with prompt recognition and a change in therapy to alternative antiviral agents such as foscarnet.

Original languageEnglish (US)
Pages (from-to)260-264
Number of pages5
JournalRetinal Cases and Brief Reports
Volume8
Issue number4
StatePublished - 2014
Externally publishedYes

Fingerprint

Acute Retinal Necrosis Syndrome
Human Herpesvirus 2
Foscarnet
Antiviral Agents
A 17
Ganciclovir
Acyclovir
Methylprednisolone
Complementary Therapies
Viruses
Inflammation
Pain
Infection
Therapeutics

Keywords

  • Acute retinal necrosis
  • Acyclovir resistance
  • HSV
  • HSV retinitis
  • Multidrug resistance

ASJC Scopus subject areas

  • Ophthalmology
  • Medicine(all)

Cite this

Dokey, A. T., Haug, S. J., McDonald, H. R., Cunningham, E. T., Lujan, B., Fu, A. D., & Jumper, J. M. (2014). Acute retinal necrosis secondary to multidrug-resistant herpes simplex virus 2 in an immunocompetent adolescent. Retinal Cases and Brief Reports, 8(4), 260-264.

Acute retinal necrosis secondary to multidrug-resistant herpes simplex virus 2 in an immunocompetent adolescent. / Dokey, Adrian T.; Haug, Sara J.; McDonald, H. Richard; Cunningham, Emmett T.; Lujan, Brandon; Fu, Arthur D.; Jumper, J. Michael.

In: Retinal Cases and Brief Reports, Vol. 8, No. 4, 2014, p. 260-264.

Research output: Contribution to journalArticle

Dokey, AT, Haug, SJ, McDonald, HR, Cunningham, ET, Lujan, B, Fu, AD & Jumper, JM 2014, 'Acute retinal necrosis secondary to multidrug-resistant herpes simplex virus 2 in an immunocompetent adolescent', Retinal Cases and Brief Reports, vol. 8, no. 4, pp. 260-264.
Dokey, Adrian T. ; Haug, Sara J. ; McDonald, H. Richard ; Cunningham, Emmett T. ; Lujan, Brandon ; Fu, Arthur D. ; Jumper, J. Michael. / Acute retinal necrosis secondary to multidrug-resistant herpes simplex virus 2 in an immunocompetent adolescent. In: Retinal Cases and Brief Reports. 2014 ; Vol. 8, No. 4. pp. 260-264.
@article{75fe713bf9664afa9e842b225c5d208a,
title = "Acute retinal necrosis secondary to multidrug-resistant herpes simplex virus 2 in an immunocompetent adolescent",
abstract = "Purpose: To report the clinical course of a patient with acute retinal necrosis resulting from a multidrug-resistant strain of herpes simplex virus 2. Methods: Observational case report. Results: A 17-year-old man with no identifiable immune deficiency presented with pain and decreased vision in his left eye. He had dense anterior and posterior segment inflammation with retinal whitening suggestive of acute retinal necrosis, which progressed despite treatment with intravenous acyclovir, methylprednisolone, and ganciclovir. A transition to intravitreal and intravenous foscarnet led to clinical improvement. Genetic analysis revealed the etiology to be a multidrug-resistant strain of herpes simplex virus 2. Conclusion: Antiviral resistance is an uncommon finding among viruses causing acute retinal necrosis in immunocompetent patients. Patients with these infections may be adequately treated with prompt recognition and a change in therapy to alternative antiviral agents such as foscarnet.",
keywords = "Acute retinal necrosis, Acyclovir resistance, HSV, HSV retinitis, Multidrug resistance",
author = "Dokey, {Adrian T.} and Haug, {Sara J.} and McDonald, {H. Richard} and Cunningham, {Emmett T.} and Brandon Lujan and Fu, {Arthur D.} and Jumper, {J. Michael}",
year = "2014",
language = "English (US)",
volume = "8",
pages = "260--264",
journal = "Retinal Cases and Brief Reports",
issn = "1935-1089",
publisher = "Lippincott Williams and Wilkins",
number = "4",

}

TY - JOUR

T1 - Acute retinal necrosis secondary to multidrug-resistant herpes simplex virus 2 in an immunocompetent adolescent

AU - Dokey, Adrian T.

AU - Haug, Sara J.

AU - McDonald, H. Richard

AU - Cunningham, Emmett T.

AU - Lujan, Brandon

AU - Fu, Arthur D.

AU - Jumper, J. Michael

PY - 2014

Y1 - 2014

N2 - Purpose: To report the clinical course of a patient with acute retinal necrosis resulting from a multidrug-resistant strain of herpes simplex virus 2. Methods: Observational case report. Results: A 17-year-old man with no identifiable immune deficiency presented with pain and decreased vision in his left eye. He had dense anterior and posterior segment inflammation with retinal whitening suggestive of acute retinal necrosis, which progressed despite treatment with intravenous acyclovir, methylprednisolone, and ganciclovir. A transition to intravitreal and intravenous foscarnet led to clinical improvement. Genetic analysis revealed the etiology to be a multidrug-resistant strain of herpes simplex virus 2. Conclusion: Antiviral resistance is an uncommon finding among viruses causing acute retinal necrosis in immunocompetent patients. Patients with these infections may be adequately treated with prompt recognition and a change in therapy to alternative antiviral agents such as foscarnet.

AB - Purpose: To report the clinical course of a patient with acute retinal necrosis resulting from a multidrug-resistant strain of herpes simplex virus 2. Methods: Observational case report. Results: A 17-year-old man with no identifiable immune deficiency presented with pain and decreased vision in his left eye. He had dense anterior and posterior segment inflammation with retinal whitening suggestive of acute retinal necrosis, which progressed despite treatment with intravenous acyclovir, methylprednisolone, and ganciclovir. A transition to intravitreal and intravenous foscarnet led to clinical improvement. Genetic analysis revealed the etiology to be a multidrug-resistant strain of herpes simplex virus 2. Conclusion: Antiviral resistance is an uncommon finding among viruses causing acute retinal necrosis in immunocompetent patients. Patients with these infections may be adequately treated with prompt recognition and a change in therapy to alternative antiviral agents such as foscarnet.

KW - Acute retinal necrosis

KW - Acyclovir resistance

KW - HSV

KW - HSV retinitis

KW - Multidrug resistance

UR - http://www.scopus.com/inward/record.url?scp=84926020112&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84926020112&partnerID=8YFLogxK

M3 - Article

C2 - 25372523

AN - SCOPUS:84926020112

VL - 8

SP - 260

EP - 264

JO - Retinal Cases and Brief Reports

JF - Retinal Cases and Brief Reports

SN - 1935-1089

IS - 4

ER -