Acute retinal necrosis caused by reactivation of herpes simplex virus type 2

W. S. Thompson; W. W. Culbertson; W. E. Smiddy; J. E. Robertson; J. T. Rosenbaum

doi:10.1016/S0002-9394(14)72900-9

Acute retinal necrosis caused by reactivation of herpes simplex virus type 2

W. S. Thompson, W. W. Culbertson, W. E. Smiddy, J. E. Robertson, J. T. Rosenbaum

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93 Scopus citations

Abstract

Acute retinal necrosis is a severe form of necrotizing retinitis. Acute retinal necrosis has been demonstrated to be caused by varicella-zoster virus and herpes simplex virus type 1. We treated three patients with acute retinal necrosis apparently caused by recrudescence of latent herpes simplex virus type 2. Primary viral infection was probably congenital, with documented perinatal herpes simplex virus type 2 infection in two patients. Bilateral chorioretinal scars were present in two patients, neither of whom had a history of ocular herpetic infection, suggesting that earlier subclinical chorioretinitis had occurred. In each case, periocular trauma preceded the development of retinitis by two to three weeks. These cases are evidently caused by trauma-induced reactivation of latent virus rather than the onset of a primary infection.

Original language	English (US)
Pages (from-to)	205-211
Number of pages	7
Journal	American journal of ophthalmology
Volume	118
Issue number	2
DOIs	https://doi.org/10.1016/S0002-9394(14)72900-9
State	Published - 1994
Externally published	Yes

ASJC Scopus subject areas

Ophthalmology

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@article{3e0f52b1906d4ddb890086748e7a543f,

title = "Acute retinal necrosis caused by reactivation of herpes simplex virus type 2",

abstract = "Acute retinal necrosis is a severe form of necrotizing retinitis. Acute retinal necrosis has been demonstrated to be caused by varicella-zoster virus and herpes simplex virus type 1. We treated three patients with acute retinal necrosis apparently caused by recrudescence of latent herpes simplex virus type 2. Primary viral infection was probably congenital, with documented perinatal herpes simplex virus type 2 infection in two patients. Bilateral chorioretinal scars were present in two patients, neither of whom had a history of ocular herpetic infection, suggesting that earlier subclinical chorioretinitis had occurred. In each case, periocular trauma preceded the development of retinitis by two to three weeks. These cases are evidently caused by trauma-induced reactivation of latent virus rather than the onset of a primary infection.",

author = "Thompson, {W. S.} and Culbertson, {W. W.} and Smiddy, {W. E.} and Robertson, {J. E.} and Rosenbaum, {J. T.}",

note = "Funding Information: From the Bascom Palmer Eye Institute, Miami, Florida (Drs. Thompson, Culbertson, and Smiddy); the Casey Eye Institute (Drs. Robertson and Rosenbaum) and the Departments of Medicine andCell Biology (Dr. Rosen-baum), and Oregon Health Sciences University, Portland, Oregon. This study was supported in part by grants EY06484 and EY07373 from the National Institutes of Health and by an unrestricted grant from Research to Prevent Blindness, Inc., New York, New York.",

year = "1994",

doi = "10.1016/S0002-9394(14)72900-9",

language = "English (US)",

volume = "118",

pages = "205--211",

journal = "American journal of ophthalmology",

issn = "0002-9394",

publisher = "Elsevier USA",

number = "2",

}

TY - JOUR

T1 - Acute retinal necrosis caused by reactivation of herpes simplex virus type 2

AU - Thompson, W. S.

AU - Culbertson, W. W.

AU - Smiddy, W. E.

AU - Robertson, J. E.

AU - Rosenbaum, J. T.

N1 - Funding Information: From the Bascom Palmer Eye Institute, Miami, Florida (Drs. Thompson, Culbertson, and Smiddy); the Casey Eye Institute (Drs. Robertson and Rosenbaum) and the Departments of Medicine andCell Biology (Dr. Rosen-baum), and Oregon Health Sciences University, Portland, Oregon. This study was supported in part by grants EY06484 and EY07373 from the National Institutes of Health and by an unrestricted grant from Research to Prevent Blindness, Inc., New York, New York.

PY - 1994

Y1 - 1994

N2 - Acute retinal necrosis is a severe form of necrotizing retinitis. Acute retinal necrosis has been demonstrated to be caused by varicella-zoster virus and herpes simplex virus type 1. We treated three patients with acute retinal necrosis apparently caused by recrudescence of latent herpes simplex virus type 2. Primary viral infection was probably congenital, with documented perinatal herpes simplex virus type 2 infection in two patients. Bilateral chorioretinal scars were present in two patients, neither of whom had a history of ocular herpetic infection, suggesting that earlier subclinical chorioretinitis had occurred. In each case, periocular trauma preceded the development of retinitis by two to three weeks. These cases are evidently caused by trauma-induced reactivation of latent virus rather than the onset of a primary infection.

AB - Acute retinal necrosis is a severe form of necrotizing retinitis. Acute retinal necrosis has been demonstrated to be caused by varicella-zoster virus and herpes simplex virus type 1. We treated three patients with acute retinal necrosis apparently caused by recrudescence of latent herpes simplex virus type 2. Primary viral infection was probably congenital, with documented perinatal herpes simplex virus type 2 infection in two patients. Bilateral chorioretinal scars were present in two patients, neither of whom had a history of ocular herpetic infection, suggesting that earlier subclinical chorioretinitis had occurred. In each case, periocular trauma preceded the development of retinitis by two to three weeks. These cases are evidently caused by trauma-induced reactivation of latent virus rather than the onset of a primary infection.

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Acute retinal necrosis caused by reactivation of herpes simplex virus type 2

Abstract

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