Acute promyelocytic leukemia presenting with features of metastatic osseous disease

Carmen Winters, Andy Chen, Stephen Moore, Elie Traer, Jennifer Dunlap

Research output: Contribution to journalArticle

Abstract

Acute promyelocytic leukemia (APL) is a distinct subtype of acute myeloid leukemia defined by a balanced translocation between chromosomes 15 and 17 resulting in fusion of the promyelocytic leukemia gene (PML) on chromosome 15 with the retinoic acid receptor-alpha gene (RARα) on chromosome 17. APL often presents with pancytopenia and is associated with a life threatening coagulopathy making prompt diagnosis and initiation of therapy critical. We report an unusual case of APL in a 59 year old female without peripheral blood abnormalities or diffuse marrow involvement. Clinical and radiographic findings were initially interpreted as metastatic osseous disease but ultimately found to be APL.

Original languageEnglish (US)
Pages (from-to)36-37
Number of pages2
JournalLeukemia Research Reports
Volume9
DOIs
StatePublished - Jan 1 2018

ASJC Scopus subject areas

  • Hematology
  • Oncology

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