Acute promyelocytic leukemia presenting with features of metastatic osseous disease

Carmen Winters, Andy Chen, Stephen Moore, Elie Traer, Jennifer Dunlap

Research output: Contribution to journalArticle

Abstract

Acute promyelocytic leukemia (APL) is a distinct subtype of acute myeloid leukemia defined by a balanced translocation between chromosomes 15 and 17 resulting in fusion of the promyelocytic leukemia gene (PML) on chromosome 15 with the retinoic acid receptor-alpha gene (RARα) on chromosome 17. APL often presents with pancytopenia and is associated with a life threatening coagulopathy making prompt diagnosis and initiation of therapy critical. We report an unusual case of APL in a 59 year old female without peripheral blood abnormalities or diffuse marrow involvement. Clinical and radiographic findings were initially interpreted as metastatic osseous disease but ultimately found to be APL.

Original languageEnglish (US)
Pages (from-to)36-37
Number of pages2
JournalLeukemia Research Reports
Volume9
DOIs
StatePublished - Jan 1 2018

Fingerprint

Acute Promyelocytic Leukemia
Chromosomes, Human, Pair 15
Chromosomes, Human, Pair 17
Pancytopenia
Acute Myeloid Leukemia
Genes
Leukemia
Bone Marrow
Therapeutics

ASJC Scopus subject areas

  • Hematology
  • Oncology

Cite this

Acute promyelocytic leukemia presenting with features of metastatic osseous disease. / Winters, Carmen; Chen, Andy; Moore, Stephen; Traer, Elie; Dunlap, Jennifer.

In: Leukemia Research Reports, Vol. 9, 01.01.2018, p. 36-37.

Research output: Contribution to journalArticle

@article{278f2ac3e5604c53b9f9775f1eb7a979,
title = "Acute promyelocytic leukemia presenting with features of metastatic osseous disease",
abstract = "Acute promyelocytic leukemia (APL) is a distinct subtype of acute myeloid leukemia defined by a balanced translocation between chromosomes 15 and 17 resulting in fusion of the promyelocytic leukemia gene (PML) on chromosome 15 with the retinoic acid receptor-alpha gene (RARα) on chromosome 17. APL often presents with pancytopenia and is associated with a life threatening coagulopathy making prompt diagnosis and initiation of therapy critical. We report an unusual case of APL in a 59 year old female without peripheral blood abnormalities or diffuse marrow involvement. Clinical and radiographic findings were initially interpreted as metastatic osseous disease but ultimately found to be APL.",
author = "Carmen Winters and Andy Chen and Stephen Moore and Elie Traer and Jennifer Dunlap",
year = "2018",
month = "1",
day = "1",
doi = "10.1016/j.lrr.2018.02.003",
language = "English (US)",
volume = "9",
pages = "36--37",
journal = "Leukemia Research Reports",
issn = "2213-0489",
publisher = "Elsevier Limited",

}

TY - JOUR

T1 - Acute promyelocytic leukemia presenting with features of metastatic osseous disease

AU - Winters, Carmen

AU - Chen, Andy

AU - Moore, Stephen

AU - Traer, Elie

AU - Dunlap, Jennifer

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Acute promyelocytic leukemia (APL) is a distinct subtype of acute myeloid leukemia defined by a balanced translocation between chromosomes 15 and 17 resulting in fusion of the promyelocytic leukemia gene (PML) on chromosome 15 with the retinoic acid receptor-alpha gene (RARα) on chromosome 17. APL often presents with pancytopenia and is associated with a life threatening coagulopathy making prompt diagnosis and initiation of therapy critical. We report an unusual case of APL in a 59 year old female without peripheral blood abnormalities or diffuse marrow involvement. Clinical and radiographic findings were initially interpreted as metastatic osseous disease but ultimately found to be APL.

AB - Acute promyelocytic leukemia (APL) is a distinct subtype of acute myeloid leukemia defined by a balanced translocation between chromosomes 15 and 17 resulting in fusion of the promyelocytic leukemia gene (PML) on chromosome 15 with the retinoic acid receptor-alpha gene (RARα) on chromosome 17. APL often presents with pancytopenia and is associated with a life threatening coagulopathy making prompt diagnosis and initiation of therapy critical. We report an unusual case of APL in a 59 year old female without peripheral blood abnormalities or diffuse marrow involvement. Clinical and radiographic findings were initially interpreted as metastatic osseous disease but ultimately found to be APL.

UR - http://www.scopus.com/inward/record.url?scp=85042925322&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85042925322&partnerID=8YFLogxK

U2 - 10.1016/j.lrr.2018.02.003

DO - 10.1016/j.lrr.2018.02.003

M3 - Article

AN - SCOPUS:85042925322

VL - 9

SP - 36

EP - 37

JO - Leukemia Research Reports

JF - Leukemia Research Reports

SN - 2213-0489

ER -