Acute promyelocytic leukaemia in the all trans retinoic acid era

Thomas G. DeLoughery, Scott H. Goodnight

    Research output: Contribution to journalReview article

    1 Scopus citations

    Abstract

    Bleeding diathesis is a common complication of acute promyelocyctic leukaemia (APL). Multiple haemostatic defects are found in most patients with APL, which often worsen following cytoreductive chemotherapy. Besides thrombocytopenia, most patients develop disseminated intravascular coagulation, systemic fibrinolysis or both. A major aim in treating haemostatic defects of APL is to prevent death or disability from bleeding until chemotherapy clears the malignant promyelocytes from the blood and bone marrow. The therapeutic options are discussed in this review and practical guidelines for treatment are outlined.

    Original languageEnglish (US)
    Pages (from-to)233-240
    Number of pages8
    JournalMedical Oncology
    Volume13
    Issue number4
    StatePublished - Dec 1 1996

    Keywords

    • haemorrhage
    • promyelocytic leukaemia
    • retinoic acid
    • thrombosis

    ASJC Scopus subject areas

    • Hematology
    • Oncology
    • Cancer Research

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