Acute neurologic decompensation in an infant with cobalamin deficiency exposed to nitrous oxide

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After exposure to nitrous oxide, an infant with unrecognized cobalamin deficiency developed neurologic deterioration and pancytopenia. Hematologic recovery and partial resolution of his neurologic changes followed repletion of the vitamin. Nitrous oxide depletes bioavailable cobalamin and may be a dangerous anesthetic in patients with cobalamin deficiency.

Original languageEnglish (US)
Pages (from-to)427-428
Number of pages2
JournalJournal of Pediatrics
Issue number3
Publication statusPublished - 2000


ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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