Acute myocardial infarction

Contrast-enhanced multi-detector row CT in a porcine model

Udo Hoffmann, Ryan Millea, Christian Enzweiler, Maros Ferencik, Scott Gulick, Jim Titus, Stephan Achenbach, Dylan Kwait, David Sosnovik, Thomas J. Brady

Research output: Contribution to journalArticle

116 Citations (Scopus)

Abstract

PURPOSE: To assess the role of contrast material-enhanced retrospectively electrocardiographically (ECG) gated multi-detector row computed tomography (CT) in the detection of acute myocardial infarction in a porcine model of total coronary occlusion. MATERIALS AND METHODS: Seven Yorkshire farm pigs were studied with contrast-enhanced retrospectively ECG-gated multi-detector row CT 3 hours after total occlusion of the distal left anterior descending artery (n = 5) or the second diagonal branch (n = 2). Reformatted short-axis end-systolic and end-diastolic CT data sets were assessed for myocardial perfusion deficits, coronary occlusion, and abnormal myocardial wall motion. Perfusion deficits were compared with microsphere-determined blood flow and triphenyltetrazolium chloride (TTC)-stained tissue samples for infarct assessment by using Bland-Altman analysis and analysis of variance. RESULTS: Myocardial perfusion deficits, occlusion of the left anterior descending artery or second diagonal branch, and akinesis of the infarcted segment were identified in all five animals that completed the study. One animal died, and one data set had nondiagnostic image quality. The CT end-diastolic (mean, 16.1% ± 4.8 [SD]; range, 8.6%-22.2%) and end-systolic (mean, 17.0% ± 6.4; range, 8.7%-26.8%) volume of perfusion deficit was similar to that of infarcted tissue at TTC staining (mean, 13.6% ± 6.0; range, 7.8%-30.9%). Infarcted myocardium at CT demonstrated a 76.1% reduction in microsphere-determined blood flow and a significant reduction of myocardial CT attenuation compared with normal myocardium (P <.01). Myocardial wall motion analysis demonstrated absence of systolic wall thickening in infarcted myocardium. CONCLUSION: Multi-detector row CT with retrospective ECG gating permits the detection and further characterization of acute myocardial infarction in a porcine model of complete coronary occlusion.

Original languageEnglish (US)
Pages (from-to)697-701
Number of pages5
JournalRadiology
Volume231
Issue number3
DOIs
StatePublished - Jun 2004
Externally publishedYes

Fingerprint

Swine
Myocardial Infarction
Tomography
Coronary Occlusion
Perfusion
Myocardium
Microspheres
Arteries
Contrast Media
Analysis of Variance
Staining and Labeling
Datasets
triphenyltetrazolium

Keywords

  • Animals
  • Computed tomography (CT), Angiography
  • Computed tomography (CT), experimental studies
  • Myocardium, infarction

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

Cite this

Hoffmann, U., Millea, R., Enzweiler, C., Ferencik, M., Gulick, S., Titus, J., ... Brady, T. J. (2004). Acute myocardial infarction: Contrast-enhanced multi-detector row CT in a porcine model. Radiology, 231(3), 697-701. https://doi.org/10.1148/radiol.2313030132

Acute myocardial infarction : Contrast-enhanced multi-detector row CT in a porcine model. / Hoffmann, Udo; Millea, Ryan; Enzweiler, Christian; Ferencik, Maros; Gulick, Scott; Titus, Jim; Achenbach, Stephan; Kwait, Dylan; Sosnovik, David; Brady, Thomas J.

In: Radiology, Vol. 231, No. 3, 06.2004, p. 697-701.

Research output: Contribution to journalArticle

Hoffmann, U, Millea, R, Enzweiler, C, Ferencik, M, Gulick, S, Titus, J, Achenbach, S, Kwait, D, Sosnovik, D & Brady, TJ 2004, 'Acute myocardial infarction: Contrast-enhanced multi-detector row CT in a porcine model', Radiology, vol. 231, no. 3, pp. 697-701. https://doi.org/10.1148/radiol.2313030132
Hoffmann, Udo ; Millea, Ryan ; Enzweiler, Christian ; Ferencik, Maros ; Gulick, Scott ; Titus, Jim ; Achenbach, Stephan ; Kwait, Dylan ; Sosnovik, David ; Brady, Thomas J. / Acute myocardial infarction : Contrast-enhanced multi-detector row CT in a porcine model. In: Radiology. 2004 ; Vol. 231, No. 3. pp. 697-701.
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abstract = "PURPOSE: To assess the role of contrast material-enhanced retrospectively electrocardiographically (ECG) gated multi-detector row computed tomography (CT) in the detection of acute myocardial infarction in a porcine model of total coronary occlusion. MATERIALS AND METHODS: Seven Yorkshire farm pigs were studied with contrast-enhanced retrospectively ECG-gated multi-detector row CT 3 hours after total occlusion of the distal left anterior descending artery (n = 5) or the second diagonal branch (n = 2). Reformatted short-axis end-systolic and end-diastolic CT data sets were assessed for myocardial perfusion deficits, coronary occlusion, and abnormal myocardial wall motion. Perfusion deficits were compared with microsphere-determined blood flow and triphenyltetrazolium chloride (TTC)-stained tissue samples for infarct assessment by using Bland-Altman analysis and analysis of variance. RESULTS: Myocardial perfusion deficits, occlusion of the left anterior descending artery or second diagonal branch, and akinesis of the infarcted segment were identified in all five animals that completed the study. One animal died, and one data set had nondiagnostic image quality. The CT end-diastolic (mean, 16.1{\%} ± 4.8 [SD]; range, 8.6{\%}-22.2{\%}) and end-systolic (mean, 17.0{\%} ± 6.4; range, 8.7{\%}-26.8{\%}) volume of perfusion deficit was similar to that of infarcted tissue at TTC staining (mean, 13.6{\%} ± 6.0; range, 7.8{\%}-30.9{\%}). Infarcted myocardium at CT demonstrated a 76.1{\%} reduction in microsphere-determined blood flow and a significant reduction of myocardial CT attenuation compared with normal myocardium (P <.01). Myocardial wall motion analysis demonstrated absence of systolic wall thickening in infarcted myocardium. CONCLUSION: Multi-detector row CT with retrospective ECG gating permits the detection and further characterization of acute myocardial infarction in a porcine model of complete coronary occlusion.",
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T2 - Contrast-enhanced multi-detector row CT in a porcine model

AU - Hoffmann, Udo

AU - Millea, Ryan

AU - Enzweiler, Christian

AU - Ferencik, Maros

AU - Gulick, Scott

AU - Titus, Jim

AU - Achenbach, Stephan

AU - Kwait, Dylan

AU - Sosnovik, David

AU - Brady, Thomas J.

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N2 - PURPOSE: To assess the role of contrast material-enhanced retrospectively electrocardiographically (ECG) gated multi-detector row computed tomography (CT) in the detection of acute myocardial infarction in a porcine model of total coronary occlusion. MATERIALS AND METHODS: Seven Yorkshire farm pigs were studied with contrast-enhanced retrospectively ECG-gated multi-detector row CT 3 hours after total occlusion of the distal left anterior descending artery (n = 5) or the second diagonal branch (n = 2). Reformatted short-axis end-systolic and end-diastolic CT data sets were assessed for myocardial perfusion deficits, coronary occlusion, and abnormal myocardial wall motion. Perfusion deficits were compared with microsphere-determined blood flow and triphenyltetrazolium chloride (TTC)-stained tissue samples for infarct assessment by using Bland-Altman analysis and analysis of variance. RESULTS: Myocardial perfusion deficits, occlusion of the left anterior descending artery or second diagonal branch, and akinesis of the infarcted segment were identified in all five animals that completed the study. One animal died, and one data set had nondiagnostic image quality. The CT end-diastolic (mean, 16.1% ± 4.8 [SD]; range, 8.6%-22.2%) and end-systolic (mean, 17.0% ± 6.4; range, 8.7%-26.8%) volume of perfusion deficit was similar to that of infarcted tissue at TTC staining (mean, 13.6% ± 6.0; range, 7.8%-30.9%). Infarcted myocardium at CT demonstrated a 76.1% reduction in microsphere-determined blood flow and a significant reduction of myocardial CT attenuation compared with normal myocardium (P <.01). Myocardial wall motion analysis demonstrated absence of systolic wall thickening in infarcted myocardium. CONCLUSION: Multi-detector row CT with retrospective ECG gating permits the detection and further characterization of acute myocardial infarction in a porcine model of complete coronary occlusion.

AB - PURPOSE: To assess the role of contrast material-enhanced retrospectively electrocardiographically (ECG) gated multi-detector row computed tomography (CT) in the detection of acute myocardial infarction in a porcine model of total coronary occlusion. MATERIALS AND METHODS: Seven Yorkshire farm pigs were studied with contrast-enhanced retrospectively ECG-gated multi-detector row CT 3 hours after total occlusion of the distal left anterior descending artery (n = 5) or the second diagonal branch (n = 2). Reformatted short-axis end-systolic and end-diastolic CT data sets were assessed for myocardial perfusion deficits, coronary occlusion, and abnormal myocardial wall motion. Perfusion deficits were compared with microsphere-determined blood flow and triphenyltetrazolium chloride (TTC)-stained tissue samples for infarct assessment by using Bland-Altman analysis and analysis of variance. RESULTS: Myocardial perfusion deficits, occlusion of the left anterior descending artery or second diagonal branch, and akinesis of the infarcted segment were identified in all five animals that completed the study. One animal died, and one data set had nondiagnostic image quality. The CT end-diastolic (mean, 16.1% ± 4.8 [SD]; range, 8.6%-22.2%) and end-systolic (mean, 17.0% ± 6.4; range, 8.7%-26.8%) volume of perfusion deficit was similar to that of infarcted tissue at TTC staining (mean, 13.6% ± 6.0; range, 7.8%-30.9%). Infarcted myocardium at CT demonstrated a 76.1% reduction in microsphere-determined blood flow and a significant reduction of myocardial CT attenuation compared with normal myocardium (P <.01). Myocardial wall motion analysis demonstrated absence of systolic wall thickening in infarcted myocardium. CONCLUSION: Multi-detector row CT with retrospective ECG gating permits the detection and further characterization of acute myocardial infarction in a porcine model of complete coronary occlusion.

KW - Animals

KW - Computed tomography (CT), Angiography

KW - Computed tomography (CT), experimental studies

KW - Myocardium, infarction

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