We describe the first case of a FLT-3 mutated AML in a healthy donor, 3 years after recombinant human granulocyte colony stimulating factor (rhG-CSF)-mobilized peripheral blood stem cell (PBSC) harvest. The patient had a myeloablative (MA) matched unrelated donor (MUD) stem cell transplant (SCT) for refractory AML. However, he experienced a secondary graft failure. He had a second non myeloablative (NMA) on day +75 from a second MUD. He achieved a complete neutrophil and platelet engraftment. After 4 years of follow up, he is alive in complete remission with full second donor chimerism.
- Peripheral blood stem cell
- Recombinant human granulocyte colony-stimulating factor
- Stem cell donor
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