Acute myeloid leukemia developing in a granulocyte colony-stimulating factor-mobilized stem cell donor: A case report and review of the literature

Housam Haddad, Manida Wungjiranirun, Usama Gergis

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

We describe the first case of a FLT-3 mutated AML in a healthy donor, 3 years after recombinant human granulocyte colony stimulating factor (rhG-CSF)-mobilized peripheral blood stem cell (PBSC) harvest. The patient had a myeloablative (MA) matched unrelated donor (MUD) stem cell transplant (SCT) for refractory AML. However, he experienced a secondary graft failure. He had a second non myeloablative (NMA) on day +75 from a second MUD. He achieved a complete neutrophil and platelet engraftment. After 4 years of follow up, he is alive in complete remission with full second donor chimerism.

Original languageEnglish (US)
Pages (from-to)123-125
Number of pages3
JournalHematology/ Oncology and Stem Cell Therapy
Volume9
Issue number3
DOIs
StatePublished - 2016
Externally publishedYes

Keywords

  • Filgrastim
  • Peripheral blood stem cell
  • Recombinant human granulocyte colony-stimulating factor
  • Stem cell donor

ASJC Scopus subject areas

  • Hematology
  • Oncology

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