TY - JOUR
T1 - Acute kidney injury in older adults
AU - Anderson, Sharon
AU - Eldadah, Basil
AU - Halter, Jeffrey B.
AU - Hazzard, William R.
AU - Himmelfarb, Jonathan
AU - Horne, Frances Mc Farland
AU - Kimmel, Paul L.
AU - Molitoris, Bruce A.
AU - Murthy, Mahadev
AU - O'Hare, Ann M.
AU - Schmader, Kenneth E.
AU - High, Kevin P.
PY - 2011/1
Y1 - 2011/1
N2 - Aging kidneys undergo structural and functional changes that decrease autoregulatory capacity and increase susceptibility to acute injury. Acute kidney injury associates with duration and location of hospitalization, mortality risk, progression to chronic kidney disease, and functional status in daily living. Definition and diagnosis of acute kidney injury are based on changes in creatinine, which is an inadequate marker and might identify patients when it is too late. The incidence of acute kidney injury is rising and increases with advancing age, yet clinical studies have been slow to address geriatric issues or the heterogeneity in etiologies, outcomes, or patient preferences among the elderly. Here we examine some of the current literature, identify knowledge gaps, and suggest potential research questions regarding acute kidney injury in older adults. Answering these questions will facilitate the integration of geriatric issues into future mechanistic and clinical studies that affect management and care of acute kidney injury.
AB - Aging kidneys undergo structural and functional changes that decrease autoregulatory capacity and increase susceptibility to acute injury. Acute kidney injury associates with duration and location of hospitalization, mortality risk, progression to chronic kidney disease, and functional status in daily living. Definition and diagnosis of acute kidney injury are based on changes in creatinine, which is an inadequate marker and might identify patients when it is too late. The incidence of acute kidney injury is rising and increases with advancing age, yet clinical studies have been slow to address geriatric issues or the heterogeneity in etiologies, outcomes, or patient preferences among the elderly. Here we examine some of the current literature, identify knowledge gaps, and suggest potential research questions regarding acute kidney injury in older adults. Answering these questions will facilitate the integration of geriatric issues into future mechanistic and clinical studies that affect management and care of acute kidney injury.
UR - http://www.scopus.com/inward/record.url?scp=78651389275&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=78651389275&partnerID=8YFLogxK
U2 - 10.1681/ASN.2010090934
DO - 10.1681/ASN.2010090934
M3 - Article
C2 - 21209252
AN - SCOPUS:78651389275
SN - 1046-6673
VL - 22
SP - 28
EP - 38
JO - Journal of the American Society of Nephrology
JF - Journal of the American Society of Nephrology
IS - 1
ER -