Acute Hepatic Failure Associated with the Use of Sodium Valproate: Report of Two Fatal Cases

Frederick J. Suchy; William F. Balistreri; John J. Buchino; Judith M. Sondheimer; Stephen R. Bates; Gregory L. Kearns; John D. Stull; Kevin E. Bove

doi:10.1056/NEJM197904263001706

Acute Hepatic Failure Associated with the Use of Sodium Valproate: Report of Two Fatal Cases

Frederick J. Suchy, William F. Balistreri, John J. Buchino, Judith M. Sondheimer, Stephen R. Bates, Gregory L. Kearns, John D. Stull, Kevin E. Bove

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Abstract

SODIUM valproate, a recently introduced anticonvulsant, is particularly useful in the management of absence seizures and has gained widespread popularity.¹ Initial European studies reported infrequent side effects² ³ ⁴; however, there have been undocumented reports of at least six cases of severe hepatotoxicity in patients from both the United Kingdom and the United States.⁵^,⁶ Detailed clinical and pathological features of these cases have not been reported, but most patients had received multiple anticonvulsants in addition to sodium valproate. Five of them died in hepatic failure. In this report, we describe the development of acute hepatic failure associated with unusual hepatic histopathologic.

Original language	English (US)
Pages (from-to)	962-966
Number of pages	5
Journal	New England Journal of Medicine
Volume	300
Issue number	17
DOIs	https://doi.org/10.1056/NEJM197904263001706
State	Published - Apr 26 1979
Externally published	Yes

ASJC Scopus subject areas

General Medicine

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@article{1b74c303b99547858c501bdce932c005,

title = "Acute Hepatic Failure Associated with the Use of Sodium Valproate: Report of Two Fatal Cases",

abstract = "SODIUM valproate, a recently introduced anticonvulsant, is particularly useful in the management of absence seizures and has gained widespread popularity.1 Initial European studies reported infrequent side effects2 3 4; however, there have been undocumented reports of at least six cases of severe hepatotoxicity in patients from both the United Kingdom and the United States.5,6 Detailed clinical and pathological features of these cases have not been reported, but most patients had received multiple anticonvulsants in addition to sodium valproate. Five of them died in hepatic failure. In this report, we describe the development of acute hepatic failure associated with unusual hepatic histopathologic.",

author = "Suchy, {Frederick J.} and Balistreri, {William F.} and Buchino, {John J.} and Sondheimer, {Judith M.} and Bates, {Stephen R.} and Kearns, {Gregory L.} and Stull, {John D.} and Bove, {Kevin E.}",

year = "1979",

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language = "English (US)",

volume = "300",

pages = "962--966",

journal = "New England Journal of Medicine",

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TY - JOUR

T1 - Acute Hepatic Failure Associated with the Use of Sodium Valproate

T2 - Report of Two Fatal Cases

AU - Suchy, Frederick J.

AU - Balistreri, William F.

AU - Buchino, John J.

AU - Sondheimer, Judith M.

AU - Bates, Stephen R.

AU - Kearns, Gregory L.

AU - Stull, John D.

AU - Bove, Kevin E.

PY - 1979/4/26

Y1 - 1979/4/26

N2 - SODIUM valproate, a recently introduced anticonvulsant, is particularly useful in the management of absence seizures and has gained widespread popularity.1 Initial European studies reported infrequent side effects2 3 4; however, there have been undocumented reports of at least six cases of severe hepatotoxicity in patients from both the United Kingdom and the United States.5,6 Detailed clinical and pathological features of these cases have not been reported, but most patients had received multiple anticonvulsants in addition to sodium valproate. Five of them died in hepatic failure. In this report, we describe the development of acute hepatic failure associated with unusual hepatic histopathologic.

AB - SODIUM valproate, a recently introduced anticonvulsant, is particularly useful in the management of absence seizures and has gained widespread popularity.1 Initial European studies reported infrequent side effects2 3 4; however, there have been undocumented reports of at least six cases of severe hepatotoxicity in patients from both the United Kingdom and the United States.5,6 Detailed clinical and pathological features of these cases have not been reported, but most patients had received multiple anticonvulsants in addition to sodium valproate. Five of them died in hepatic failure. In this report, we describe the development of acute hepatic failure associated with unusual hepatic histopathologic.

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DO - 10.1056/NEJM197904263001706

M3 - Article

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AN - SCOPUS:0018763194

SN - 0028-4793

VL - 300

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JO - New England Journal of Medicine

JF - New England Journal of Medicine

IS - 17

ER -

Acute Hepatic Failure Associated with the Use of Sodium Valproate: Report of Two Fatal Cases

Abstract

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