Background: Acute generalized exanthematous pustulosis (AGEP) is a generalized, nonfollicular, pustular eruption of the skin associated with fever and leukocytosis. The cause of AGEP has mainly been attributed to drugs. Objective: We report a unique case of AGEP in a 75-year-old male caused by oral fluconazole. We include clinical as well as histological illustrations of our case. Conclusion: Based on a current literature search using the MEDLINE electronic database, this is the first reported case of AGEP arising from use of oral fluconazole. The clinical presentation, clinical course, and histology are consistent with prior reports of AGEP resulting from other drugs. AGEP should be considered a possible complication of oral fluconazole treatment.
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