Abstract
Objective: To investigate the relationship between acute exposure to air pollutants and spontaneous pregnancy loss. Design: Case-crossover study from 2007 to 2015. Setting: An academic emergency department in the Wasatch Front area of Utah. Patient(s): A total of 1,398 women who experienced spontaneous pregnancy loss events. Intervention(s): None. Main Outcome Measure(s): Odds of spontaneous pregnancy loss. Result(s): We found that a 10-ppb increase in 7-day average levels of nitrogen dioxide was associated with a 16% increase in the odds of spontaneous pregnancy loss (odds ratio [OR] = 1.16; 95% confidence interval [CI] 1.01–1.33; P=.04). A 10-μg/m 3 increase in 3-day and 7-day averages of fine particulate matter were associated with increased risk of spontaneous pregnancy loss, but the associations did not reach statistical significance (OR 3-day average = 1.09; 95% CI 0.99–1.20; P=.05) (OR 7-day average = 1.11; 95% CI 0.99–1.24; P=.06). We found no evidence of increased risk for any other metrics of nitrogen dioxide or fine particulate matter or any metric for ozone. Conclusions: We found that short-term exposure to elevated levels of air pollutants was associated with higher risk for spontaneous pregnancy loss.
Original language | English (US) |
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Pages (from-to) | 341-347 |
Number of pages | 7 |
Journal | Fertility and sterility |
Volume | 111 |
Issue number | 2 |
DOIs | |
State | Published - Feb 2019 |
Keywords
- Air pollution
- NO
- PM -PM -ultrafine
- adverse pregnancy outcomes
- female reproductive effects
ASJC Scopus subject areas
- Reproductive Medicine
- Obstetrics and Gynecology