Acute disseminated encephalomyelitis

An MRI/MRS longitudinal study

Lidia V. Gabis, David J. Panasci, Mary R. Andriola, Wei Huang

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

A clinical and radiologic diagnosis of acute disseminated encephalomyelitis was made in two children: a 6-month-old female who presented with focal seizures and thalamic and cerebral white matter lesions, and a 4.5-year-old male who presented with tremor and dystonia and had bilateral basal ganglia lesions, without evidence of active brain infection. Serial clinical and laboratory evaluations were supplemented by neuroimaging including routine magnetic resonance imaging and 1H magnetic resonance spectroscopy. They were treated symptomatically, without using steroids or intravenous immunoglobulin, and both children recovered. Single voxel 1H magnetic resonance spectroscopy data were acquired from the involved areas and from normal-appearing white matter. Abnormalities in N-acetyl-aspartate, choline, and lactate peaks were evident during the symptomatic phase, and persistence of low N-acetyl-aspartate was observed during recovery. These spectroscopic findings are consistent with neuropathologic findings of neuronal dysfunction, cellular membrane turnover, cellular infiltration, and metabolic stress in the acute phase, and with neuronal loss in the chronic phase. Gabis LV, Panasci DJ, Andriola MR, Huang W. Acute disseminated encephalomyelitis: An MRI/MRS longitudinal study.

Original languageEnglish (US)
Pages (from-to)324-329
Number of pages6
JournalPediatric Neurology
Volume30
Issue number5
DOIs
StatePublished - May 2004
Externally publishedYes

Fingerprint

Acute Disseminated Encephalomyelitis
Longitudinal Studies
Magnetic Resonance Spectroscopy
Physiological Stress
Dystonia
Intravenous Immunoglobulins
Tremor
Choline
Basal Ganglia
Neuroimaging
Lactic Acid
Seizures
Steroids
Magnetic Resonance Imaging
Membranes
Brain
Infection
N-acetylaspartate
White Matter

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health
  • Developmental Neuroscience
  • Neurology

Cite this

Acute disseminated encephalomyelitis : An MRI/MRS longitudinal study. / Gabis, Lidia V.; Panasci, David J.; Andriola, Mary R.; Huang, Wei.

In: Pediatric Neurology, Vol. 30, No. 5, 05.2004, p. 324-329.

Research output: Contribution to journalArticle

Gabis, Lidia V. ; Panasci, David J. ; Andriola, Mary R. ; Huang, Wei. / Acute disseminated encephalomyelitis : An MRI/MRS longitudinal study. In: Pediatric Neurology. 2004 ; Vol. 30, No. 5. pp. 324-329.
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