Acute cerebellar dysfunction with high‐dose ARA‐C therapy

M. C. Salinsky; R. L. Levine; J. P. Aubuchon; H. S. Schutta

doi:10.1002/1097-0142(19830201)51:3<426::AID-CNCR2820510312>3.0.CO;2-S

Acute cerebellar dysfunction with high‐dose ARA‐C therapy

M. C. Salinsky, R. L. Levine, J. P. Aubuchon, H. S. Schutta

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65 Scopus citations

Abstract

The authors report a patient with clinical and morphologic evidence of acute cerebellar toxicity after receiving high‐dose cytosine arabinoside (ARA‐C) (3000 mg/m²/12 hours) for refractory AML. Damage of Purkinje cells and dentate nucleus was demonstrated. Reversible cerebellar toxicity has previously been noted in patients on an identical regimen. Signs of cerebellar dysfunction mandate immediate cessation of highdose ARA‐C therapy.

Original language	English (US)
Pages (from-to)	426-429
Number of pages	4
Journal	Cancer
Volume	51
Issue number	3
DOIs	https://doi.org/10.1002/1097-0142(19830201)51:3<426::AID-CNCR2820510312>3.0.CO;2-S
State	Published - Feb 1 1983
Externally published	Yes

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1002/1097-0142(19830201)51:3<426::AID-CNCR2820510312>3.0.CO;2-S

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AU - Levine, R. L.

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AU - Schutta, H. S.

PY - 1983/2/1

Y1 - 1983/2/1

N2 - The authors report a patient with clinical and morphologic evidence of acute cerebellar toxicity after receiving high‐dose cytosine arabinoside (ARA‐C) (3000 mg/m2/12 hours) for refractory AML. Damage of Purkinje cells and dentate nucleus was demonstrated. Reversible cerebellar toxicity has previously been noted in patients on an identical regimen. Signs of cerebellar dysfunction mandate immediate cessation of highdose ARA‐C therapy.

AB - The authors report a patient with clinical and morphologic evidence of acute cerebellar toxicity after receiving high‐dose cytosine arabinoside (ARA‐C) (3000 mg/m2/12 hours) for refractory AML. Damage of Purkinje cells and dentate nucleus was demonstrated. Reversible cerebellar toxicity has previously been noted in patients on an identical regimen. Signs of cerebellar dysfunction mandate immediate cessation of highdose ARA‐C therapy.

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Acute cerebellar dysfunction with high‐dose ARA‐C therapy

Abstract

ASJC Scopus subject areas

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