Acute bacterial suppurative thyroiditis: A clinical review and expert opinion

John E. Paes, Kenneth D. Burman, James Cohen, Jayne Franklyn, Christopher R. McHenry, Shmuel Shoham, Richard T. Kloos

Research output: Contribution to journalArticle

69 Citations (Scopus)

Abstract

Background: Acute suppurative thyroiditis (AST) resulting from a bacterial infection is an infrequent but potentially life-threatening endocrine emergency. Traditional management of this disease has been surgery in conjunction with targeted antibiotic therapy. Recent nonrandomized reports of small series have demonstrated good outcomes using less invasive approaches. No randomized clinical trials have been performed. Here, we provide a review of the literature and an approach to this problem based on expert opinion. Methods: The literature was reviewed utilizing PubMed, and a representative case of AST was presented to a panel of experts. Endocrinology, surgery, and infectious disease experts responded to a series of questions regarding diagnosis, management, prognosis, and harm. Results: Combining a broad spectrum of clinical expertise and the published literature, the authors suggest a clinical algorithm as a guide to management, addressing both diagnosis and acute and long-term management. Conclusions: Published studies indicate a trend toward less invasive management during active inflammation and infection and regarding definite therapy. Remaining questions are presented to foster an evidence-based approach to this disease. Ideally, future randomized, controlled trials will provide data to improve the therapy and outcome of AST.

Original languageEnglish (US)
Pages (from-to)247-255
Number of pages9
JournalThyroid
Volume20
Issue number3
DOIs
StatePublished - Mar 1 2010

Fingerprint

Suppurative Thyroiditis
Expert Testimony
Randomized Controlled Trials
Endocrinology
Disease Management
Bacterial Infections
PubMed
Communicable Diseases
Emergencies
Therapeutics
Anti-Bacterial Agents
Inflammation
Infection

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Paes, J. E., Burman, K. D., Cohen, J., Franklyn, J., McHenry, C. R., Shoham, S., & Kloos, R. T. (2010). Acute bacterial suppurative thyroiditis: A clinical review and expert opinion. Thyroid, 20(3), 247-255. https://doi.org/10.1089/thy.2008.0146

Acute bacterial suppurative thyroiditis : A clinical review and expert opinion. / Paes, John E.; Burman, Kenneth D.; Cohen, James; Franklyn, Jayne; McHenry, Christopher R.; Shoham, Shmuel; Kloos, Richard T.

In: Thyroid, Vol. 20, No. 3, 01.03.2010, p. 247-255.

Research output: Contribution to journalArticle

Paes, JE, Burman, KD, Cohen, J, Franklyn, J, McHenry, CR, Shoham, S & Kloos, RT 2010, 'Acute bacterial suppurative thyroiditis: A clinical review and expert opinion', Thyroid, vol. 20, no. 3, pp. 247-255. https://doi.org/10.1089/thy.2008.0146
Paes JE, Burman KD, Cohen J, Franklyn J, McHenry CR, Shoham S et al. Acute bacterial suppurative thyroiditis: A clinical review and expert opinion. Thyroid. 2010 Mar 1;20(3):247-255. https://doi.org/10.1089/thy.2008.0146
Paes, John E. ; Burman, Kenneth D. ; Cohen, James ; Franklyn, Jayne ; McHenry, Christopher R. ; Shoham, Shmuel ; Kloos, Richard T. / Acute bacterial suppurative thyroiditis : A clinical review and expert opinion. In: Thyroid. 2010 ; Vol. 20, No. 3. pp. 247-255.
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