Acute anemic hypoxemia produces a transient depression in fetal respiratory activity

J. M. Bissonnette, Alan (Roger) Hohimer

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Isovolemic anemia was produced in 11 unanesthetized fetal sheep by withdrawal of blood and replacement with saline-dextran. Fetal hematocrit fell from 36 ± 1 to 19 ± 1% (SE). Fetal breathing movements, which were present during 34.4 ± 5.5% of 3 h before the anemia, occurred 10.1 ± 5.3, 14.8 ± 4.4, and 27.1 ± 6.7% in the 3 h following. The anemia caused a fall in arterial O2 concentration from 8.4 ± 0.3 to 3.6 ± 0.1 vol% and sagittal vein PO2 fell from 15.4 ± 0.5 to 12.4 ± 0.3 Torr. Cerebral metabolic rate during the period of anemia was 2.9 ± 0.1 ml·100 g-1·min-1, which was unchanged from the control value of 3.0 ± 0.2 ml·100 g-1·min-1. Sagittal vein PCO2 (54.2 ± 1.4 Torr) remained constant after the fetus was made anemic. We conclude that respiratory activity in the sheep fetus is depressed by anemic hypoxemia but that the effect is transient.

Original languageEnglish (US)
Pages (from-to)1942-1946
Number of pages5
JournalJournal of Applied Physiology
Volume63
Issue number5
StatePublished - 1987

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Fetal Movement
Anemia
dextran - saline drug combination
Veins
Sheep
Fetus
Hematocrit
Respiration
Hypoxia

ASJC Scopus subject areas

  • Endocrinology
  • Physiology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Acute anemic hypoxemia produces a transient depression in fetal respiratory activity. / Bissonnette, J. M.; Hohimer, Alan (Roger).

In: Journal of Applied Physiology, Vol. 63, No. 5, 1987, p. 1942-1946.

Research output: Contribution to journalArticle

Bissonnette, J. M. ; Hohimer, Alan (Roger). / Acute anemic hypoxemia produces a transient depression in fetal respiratory activity. In: Journal of Applied Physiology. 1987 ; Vol. 63, No. 5. pp. 1942-1946.
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