TY - JOUR
T1 - Acupuncture Augmentation of Lidocaine for Provoked, Localized Vulvodynia
T2 - A Feasibility and Acceptability Study
AU - Hullender Rubin, Lee E.
AU - Mist, Scott D.
AU - Schnyer, Rosa N.
AU - Chao, Maria T.
AU - Leclair, Catherine M.
N1 - Funding Information:
1Osher Center for Integrative Medicine, University of California San Francisco, San Francisco, CA; 2Department of Anesthesiology and Perioperative Medicine, Oregon Health & Science University, Portland, OR; 3Department of Nursing, University of Texas, Austin, TX; 4Osher Center for Integrative Medicine, University of California San Francisco, San Francisco, CA; and 5Department of Obstetrics and Gynecology, Oregon Health & Science University, San Francisco, CA Reprint requests to: Lee E. Hullender Rubin, DAOM, MS, BS, Osher Center for Integrative Medicine, University of California San Francisco, 1545 Divisadero St, 4th Floor San Francisco, CA 94115. E-mail: lee.hullenderrubin@ucsf.edu The authors have declared they have no conflicts of interest. This study was supported by the National Vulvodynia Association, Oregon Health & Science University Women's Health Research Unit, Council of College of Oriental Medicine, Oregon College of Oriental Medicine, and Oregon Clinical and Translational Research Institute (OCTRI), grant number (UL1TR000128) from the National Center for Advancing Translational Sciences (NCATS) at the National Institutes of Health (NIH). The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH. Data collection was completed with REDCap and funded by an Oregon Clinical and Translational Research Institute NIH NCATS grant (1UL1RR02414001). Acupuncture needles were provided by Golden Flower Chinese Herbs. IRB Status: Active, OHSU IRB # 9664. © 2019, ASCCP DOI: 10.1097/LGT.0000000000000489
Publisher Copyright:
© Lippincott Williams & Wilkins.
PY - 2019/10/1
Y1 - 2019/10/1
N2 - Objective The aim of the study was to assess the feasibility and acceptability of acupuncture's augmentation of lidocaine therapy in the treatment of provoked localized vulvodynia (PLV). Materials and Methods For 12 weeks, women with moderate to severe PLV were randomized to either 18 sessions of traditional acupuncture (TA) or non-TA (NTA). All participants applied lidocaine 5% cream 4 times daily to the vestibule. Feasibility was assessed by recruitment, enrollment, assessment completion, and blinding. Acceptability was assessed by study visit attendance and satisfaction. The primary outcome was change in tampon test scores from baseline to week 12 and follow-up at week 24. Results Nineteen women enrolled and 14 completed the study. Five withdrew because of lidocaine reaction (n = 2), inability to insert tampon (n = 1), starting a new medication (n = 1), or change in vulvar diagnosis (n = 1). Participants in both groups reported pain reduction for 12 weeks. There was no statistically significant difference between groups. Women in the TA group (n = 7) experienced less pain from baseline to 12 weeks (mean difference [MD] = 42.4 ± 19.4 and MD = 35.7 ± 17.8 at week 24). In the non-TA group (n = 7), women experienced a within-group MD of 28.7 ± 28.5 at 12 weeks and an MD of 36.7 ± 17.7. Conclusions In this early-phase research, acupuncture augmentation of lidocaine was acceptable. The study procedures, with modifications, may be feasible for future investigation. Both acupuncture techniques showed a favorable effect; however, the contribution to pain relief is undetermined.
AB - Objective The aim of the study was to assess the feasibility and acceptability of acupuncture's augmentation of lidocaine therapy in the treatment of provoked localized vulvodynia (PLV). Materials and Methods For 12 weeks, women with moderate to severe PLV were randomized to either 18 sessions of traditional acupuncture (TA) or non-TA (NTA). All participants applied lidocaine 5% cream 4 times daily to the vestibule. Feasibility was assessed by recruitment, enrollment, assessment completion, and blinding. Acceptability was assessed by study visit attendance and satisfaction. The primary outcome was change in tampon test scores from baseline to week 12 and follow-up at week 24. Results Nineteen women enrolled and 14 completed the study. Five withdrew because of lidocaine reaction (n = 2), inability to insert tampon (n = 1), starting a new medication (n = 1), or change in vulvar diagnosis (n = 1). Participants in both groups reported pain reduction for 12 weeks. There was no statistically significant difference between groups. Women in the TA group (n = 7) experienced less pain from baseline to 12 weeks (mean difference [MD] = 42.4 ± 19.4 and MD = 35.7 ± 17.8 at week 24). In the non-TA group (n = 7), women experienced a within-group MD of 28.7 ± 28.5 at 12 weeks and an MD of 36.7 ± 17.7. Conclusions In this early-phase research, acupuncture augmentation of lidocaine was acceptable. The study procedures, with modifications, may be feasible for future investigation. Both acupuncture techniques showed a favorable effect; however, the contribution to pain relief is undetermined.
KW - acupuncture
KW - dyspareunia
KW - electroacupuncture
KW - tampon test
KW - vulvodynia
UR - http://www.scopus.com/inward/record.url?scp=85072946331&partnerID=8YFLogxK
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U2 - 10.1097/LGT.0000000000000489
DO - 10.1097/LGT.0000000000000489
M3 - Article
C2 - 31592976
AN - SCOPUS:85072946331
VL - 23
SP - 279
EP - 286
JO - Journal of Lower Genital Tract Disease
JF - Journal of Lower Genital Tract Disease
SN - 1089-2591
IS - 4
ER -