Active programmable electronic devices for molecular biological analysis and diagnostics

Research output: Contribution to journalArticle

Abstract

A self-addressable, self-assembling microelectronic device is designed and fabricated to actively carry out and control multi-step and multiplex molecular biological reactions in microscopic formats. These reactions include nucleic acid hybridization, antibody/antigen reaction, diagnostics, and biopolymer synthesis. The device can be fabricated using both microlithographic and micromachining techniques. The device can electronically control the transport and attachment of specific binding entities to specific micro-locations. The specific binding entities include molecular biological molecules such as nucleic acids and polypeptides. The device can subsequently control the transport and reaction of analytes or reactants at the addressed specific microlocations. The device is able to concentrate analytes and reactants, remove non-specifically bound molecules, provide stringency control for DNA hybridization reactions, and improve the detection of analytes. The device can be electronically replicated.

Original languageEnglish (US)
Number of pages1
JournalBiotechnology Advances
Volume15
Issue number3-4
DOIs
StatePublished - Jan 1 1997
Externally publishedYes

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Equipment and Supplies
Nucleic acids
Nucleic Acids
Antigen-antibody reactions
Biopolymers
Molecules
Polypeptides
Micromachining
Microelectronics
Antigen-Antibody Reactions
Microtechnology
Nucleic Acid Hybridization
DNA
Peptides

ASJC Scopus subject areas

  • Biotechnology

Cite this

Active programmable electronic devices for molecular biological analysis and diagnostics. / Heller, Michael (Mike); Tu, Eugene.

In: Biotechnology Advances, Vol. 15, No. 3-4, 01.01.1997.

Research output: Contribution to journalArticle

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