Active management of risk in nulliparous pregnancy at term: association between a higher preventive labor induction rate and improved birth outcomes

James M. Nicholson, Morghan H. Stenson, Lisa C. Kellar, Aaron B. Caughey, George A. Macones

Research output: Contribution to journalArticle

12 Scopus citations


Objective: The objective of the study was to determine whether exposure of nulliparous women to a high rate of preventive labor induction was associated with improvement in birth health. Study Design: A risk-scoring system was used to guide the frequent use of preventive labor induction in 100 nulliparous women. The birth outcomes of this group were compared with those of 352 nulliparous women who received usual care. Cesarean delivery was the primary study outcome. The Adverse Outcome Index and the rate of uncomplicated vaginal delivery were used to measure overall birth health. Results: The exposed group experienced a higher labor induction rate (48% vs 23.6%; P < .001), a lower cesarean rate (9% vs 25.8%; adjusted odds ratio, 0.36; P = .02), and better composite birth outcomes. Conclusion: Exposure of nulliparous women to a high preventive induction rate was significantly associated with improvement in birth health. Prospective randomized trials are needed to further explore the utility of risk-guided preventive labor induction.

Original languageEnglish (US)
Pages (from-to)254.e1-254.e13
JournalAmerican journal of obstetrics and gynecology
Issue number3
StatePublished - Mar 2009



  • Adverse Outcome Index
  • birth outcomes
  • cesarean delivery
  • nulliparous
  • preventive labor induction

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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