Active clearance of corticotropin-releasing factor from the cerebrospinal fluid

Edward H. Oldfield, Heinrich M. Schulle, George P. Chrousos, Jack P. Rock, Paul L. Kornblith, Dondra L. O’Neill, David G. Poplack, Philip W. Gold, Gordon B. Cutler, Lynn Loriaux

Research output: Contribution to journalArticle

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Abstract

Intracerebroventricular injection of corticotropin-releasing factor (CRF) in animals activates behavioral, motor, metabolic and sympathetic responses similar to those seen with stress. To explore the pharmacokinetics of this peptide in the primate ventricular CSF, we determined the clearance of ovine 125I-CRF from the CSF and compared it to that of 111In-DTPA, a substance cleared by bulk How. 125I-CRF was cleared from the ventricular fluid sixfold more rapidly than bulk flow. This suggests that the CSF may be a pathway for physiological distribution of this releasing factor to active sites within the central nervous system, and that a mechanism exists for active removal of CRF from the ventricular CSF.

Original languageEnglish (US)
Pages (from-to)84-87
Number of pages4
JournalNeuroendocrinology
Volume40
Issue number1
DOIs
StatePublished - Jan 1 1985

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Keywords

  • Cerebrospinal fluid
  • Clearance
  • Corticotropin-releasing factor

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Endocrine and Autonomic Systems
  • Cellular and Molecular Neuroscience

Cite this

Oldfield, E. H., Schulle, H. M., Chrousos, G. P., Rock, J. P., Kornblith, P. L., O’Neill, D. L., Poplack, D. G., Gold, P. W., Cutler, G. B., & Loriaux, L. (1985). Active clearance of corticotropin-releasing factor from the cerebrospinal fluid. Neuroendocrinology, 40(1), 84-87. https://doi.org/10.1159/000124056