Active clearance of corticotropin-releasing factor from the cerebrospinal fluid

Edward H. Oldfield; Heinrich M. Schulle; George P. Chrousos; Jack P. Rock; Paul L. Kornblith; Dondra L. O’Neill; David G. Poplack; Philip W. Gold; Gordon B. Cutler; Lynn Loriaux

doi:10.1159/000124056

Active clearance of corticotropin-releasing factor from the cerebrospinal fluid

Edward H. Oldfield, Heinrich M. Schulle, George P. Chrousos, Jack P. Rock, Paul L. Kornblith, Dondra L. O’Neill, David G. Poplack, Philip W. Gold, Gordon B. Cutler, Lynn Loriaux

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

Intracerebroventricular injection of corticotropin-releasing factor (CRF) in animals activates behavioral, motor, metabolic and sympathetic responses similar to those seen with stress. To explore the pharmacokinetics of this peptide in the primate ventricular CSF, we determined the clearance of ovine ¹²⁵I-CRF from the CSF and compared it to that of ¹¹¹In-DTPA, a substance cleared by bulk How. ¹²⁵I-CRF was cleared from the ventricular fluid sixfold more rapidly than bulk flow. This suggests that the CSF may be a pathway for physiological distribution of this releasing factor to active sites within the central nervous system, and that a mechanism exists for active removal of CRF from the ventricular CSF.

Original language	English (US)
Pages (from-to)	84-87
Number of pages	4
Journal	Neuroendocrinology
Volume	40
Issue number	1
DOIs	https://doi.org/10.1159/000124056
State	Published - 1985
Externally published	Yes

Keywords

Cerebrospinal fluid
Clearance
Corticotropin-releasing factor

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Endocrinology
Endocrine and Autonomic Systems
Cellular and Molecular Neuroscience

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10.1159/000124056

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title = "Active clearance of corticotropin-releasing factor from the cerebrospinal fluid",

abstract = "Intracerebroventricular injection of corticotropin-releasing factor (CRF) in animals activates behavioral, motor, metabolic and sympathetic responses similar to those seen with stress. To explore the pharmacokinetics of this peptide in the primate ventricular CSF, we determined the clearance of ovine 125I-CRF from the CSF and compared it to that of 111In-DTPA, a substance cleared by bulk How. 125I-CRF was cleared from the ventricular fluid sixfold more rapidly than bulk flow. This suggests that the CSF may be a pathway for physiological distribution of this releasing factor to active sites within the central nervous system, and that a mechanism exists for active removal of CRF from the ventricular CSF.",

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year = "1985",

doi = "10.1159/000124056",

language = "English (US)",

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pages = "84--87",

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T1 - Active clearance of corticotropin-releasing factor from the cerebrospinal fluid

AU - Oldfield, Edward H.

AU - Schulle, Heinrich M.

AU - Chrousos, George P.

AU - Rock, Jack P.

AU - Kornblith, Paul L.

AU - O’Neill, Dondra L.

AU - Poplack, David G.

AU - Gold, Philip W.

AU - Cutler, Gordon B.

AU - Loriaux, Lynn

PY - 1985

Y1 - 1985

N2 - Intracerebroventricular injection of corticotropin-releasing factor (CRF) in animals activates behavioral, motor, metabolic and sympathetic responses similar to those seen with stress. To explore the pharmacokinetics of this peptide in the primate ventricular CSF, we determined the clearance of ovine 125I-CRF from the CSF and compared it to that of 111In-DTPA, a substance cleared by bulk How. 125I-CRF was cleared from the ventricular fluid sixfold more rapidly than bulk flow. This suggests that the CSF may be a pathway for physiological distribution of this releasing factor to active sites within the central nervous system, and that a mechanism exists for active removal of CRF from the ventricular CSF.

AB - Intracerebroventricular injection of corticotropin-releasing factor (CRF) in animals activates behavioral, motor, metabolic and sympathetic responses similar to those seen with stress. To explore the pharmacokinetics of this peptide in the primate ventricular CSF, we determined the clearance of ovine 125I-CRF from the CSF and compared it to that of 111In-DTPA, a substance cleared by bulk How. 125I-CRF was cleared from the ventricular fluid sixfold more rapidly than bulk flow. This suggests that the CSF may be a pathway for physiological distribution of this releasing factor to active sites within the central nervous system, and that a mechanism exists for active removal of CRF from the ventricular CSF.

KW - Cerebrospinal fluid

KW - Clearance

KW - Corticotropin-releasing factor

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Active clearance of corticotropin-releasing factor from the cerebrospinal fluid

Abstract

Keywords

ASJC Scopus subject areas

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