Activation of YAP1 is associated with poor prognosis and response to taxanes in ovarian cancer

Woojin Jeong, Sang Bae Kim, Bo Hwa Sohn, Yun Yong Park, Eun Sung Park, Sang Cheol Kim, Sung Soo Kim, Randy L. Johnson, Michael Birrer, David S.L. Bowtell, Gordon B. Mills, Anil Sood, Ju Seog Lee

Research output: Contribution to journalArticlepeer-review

41 Scopus citations

Abstract

Aim: We aimed to investigate the clinical significance of the activation of Yes-Associated Protein 1 (YAP1), a key downstream effector of Hippo tumor-suppressor pathway, in ovarian cancer. Materials and Methods: A gene expression signature reflecting activation of YAP1 was developed from gene expression data of 267 samples from patients with ovarian cancer. A refined ovarian cancer YAP1 signature was validated in an independent ovarian cancer cohort (n=185). Associations between the YAP1 signature and prognosis were assessed using Kaplan-Meier plots, the log-rank test, and a Cox proportional hazards model. Results: We identified a 612-gene expression signature reflecting YAP1 activation in ovarian cancer. In multivariate analysis, the signature was an independent predictor of overall survival (hazard ratio=1.66; 95% confidence interval=1.1 to 2.53; p=0.01). In subset analysis, the signature identified patients likely to benefit from taxane-based adjuvant chemotherapy. Conclusion: Activation of YAP1 is significantly associated with prognosis and the YAP1 signature can predict response to taxane-based adjuvant chemotherapy in patients with ovarian cancer.

Original languageEnglish (US)
Pages (from-to)811-818
Number of pages8
JournalAnticancer research
Volume34
Issue number2
StatePublished - Feb 1 2014
Externally publishedYes

Keywords

  • DNA microarrays
  • Ovarian cancer
  • Prognosis
  • Taxane
  • YAP1

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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