Activation of the CRF 2 receptor modulates skeletal muscle mass under physiological and pathological conditions

Richard T. Hinkle, Elizabeth Donnelly, David B. Cody, Steven Samuelsson, Jana S. Lange, Mary Beth Bauer, Mark Tarnopolsky, Russell J. Sheldon, Sarah C. Coste, Eric Tobar, Mary P. Stenzel-Poore, Robert J. Isfort

Research output: Contribution to journalArticle

28 Scopus citations

Abstract

Two receptors activated by the corticotropin-releasing factor (CRF) family of peptides have been identified, the CRF 1 receptor (CRF1R) and the CRF 2 receptor (CRF2R). Of these, the CRF2R is expressed in skeletal muscle. To understand the role of the CRF2R in skeletal muscle, we utilized CRFR knockout mice and CRF2R-selective agonists to modulate nerve damage and corticosteroid- and disuse-induced skeletal muscle atrophy in mice. These analyses demonstrated that activation of the CRF2R decreased nerve damage and corticosteroid- and disuse-induced skeletal muscle mass and function loss. In addition, selective activation of the CRF2R increased nonatrophy skeletal muscle mass. Thus we describe for the first time a novel activity of the CRF2R, modulation of skeletal muscle mass.

Original languageEnglish (US)
Pages (from-to)E889-E898
JournalAmerican Journal of Physiology - Endocrinology and Metabolism
Volume285
Issue number4 48-4
DOIs
StatePublished - Oct 1 2003

Keywords

  • Atrophy
  • Corticotropin-releasing factor receptor
  • Hypertrophy
  • Sauvagine
  • Urocortin II

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Physiology
  • Physiology (medical)

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    Hinkle, R. T., Donnelly, E., Cody, D. B., Samuelsson, S., Lange, J. S., Bauer, M. B., Tarnopolsky, M., Sheldon, R. J., Coste, S. C., Tobar, E., Stenzel-Poore, M. P., & Isfort, R. J. (2003). Activation of the CRF 2 receptor modulates skeletal muscle mass under physiological and pathological conditions. American Journal of Physiology - Endocrinology and Metabolism, 285(4 48-4), E889-E898. https://doi.org/10.1152/ajpendo.00081.2003