Activation of β-catenin/TCF targets following loss of the tumor suppressor SNF5

E. L. Mora-Blanco, Y. Mishina, E. J. Tillman, Y. J. Cho, C. S. Thom, S. L. Pomeroy, W. Shao, C. W.M. Roberts

Research output: Contribution to journalArticle

43 Scopus citations

Abstract

The SWI/SNF chromatin remodeling complex is a master regulator of developmental cell-fate decisions, although the key target pathways are poorly characterized. Here, we interrogated the contribution of the SWI/SNF subunit and tumor suppressor SNF5 to the regulation of developmental pathways using conditional mouse and cell culture models. We find that loss of SNF5 phenocopies β-catenin hyperactivation and that SNF5 is essential for regulating Wnt/β-catenin pathway target expression. These data provide insight into chromatin-based mechanisms that underlie developmental regulation and elucidate the emerging theme that mutation of this tumor suppressor complex can activate developmental pathways by uncoupling them from upstream control.

Original languageEnglish (US)
Pages (from-to)933-938
Number of pages6
JournalOncogene
Volume33
Issue number7
DOIs
StatePublished - Feb 13 2014

Keywords

  • Swi/Snf
  • beta-catenin
  • chromatin remodeling
  • epigenetics
  • tumor suppressor

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

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    Mora-Blanco, E. L., Mishina, Y., Tillman, E. J., Cho, Y. J., Thom, C. S., Pomeroy, S. L., Shao, W., & Roberts, C. W. M. (2014). Activation of β-catenin/TCF targets following loss of the tumor suppressor SNF5. Oncogene, 33(7), 933-938. https://doi.org/10.1038/onc.2013.37