Activation of β-catenin/TCF targets following loss of the tumor suppressor SNF5

E. L. Mora-Blanco, Y. Mishina, E. J. Tillman, Yoon-Jae Cho, C. S. Thom, S. L. Pomeroy, W. Shao, C. W.M. Roberts

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

The SWI/SNF chromatin remodeling complex is a master regulator of developmental cell-fate decisions, although the key target pathways are poorly characterized. Here, we interrogated the contribution of the SWI/SNF subunit and tumor suppressor SNF5 to the regulation of developmental pathways using conditional mouse and cell culture models. We find that loss of SNF5 phenocopies β-catenin hyperactivation and that SNF5 is essential for regulating Wnt/β-catenin pathway target expression. These data provide insight into chromatin-based mechanisms that underlie developmental regulation and elucidate the emerging theme that mutation of this tumor suppressor complex can activate developmental pathways by uncoupling them from upstream control.

Original languageEnglish (US)
Pages (from-to)933-938
Number of pages6
JournalOncogene
Volume33
Issue number7
DOIs
StatePublished - Feb 13 2014
Externally publishedYes

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Catenins
Genetic Suppression
Wnt Signaling Pathway
Chromatin Assembly and Disassembly
Chromatin
Neoplasms
Cell Culture Techniques

Keywords

  • beta-catenin
  • chromatin remodeling
  • epigenetics
  • Swi/Snf
  • tumor suppressor

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

Cite this

Mora-Blanco, E. L., Mishina, Y., Tillman, E. J., Cho, Y-J., Thom, C. S., Pomeroy, S. L., ... Roberts, C. W. M. (2014). Activation of β-catenin/TCF targets following loss of the tumor suppressor SNF5. Oncogene, 33(7), 933-938. https://doi.org/10.1038/onc.2013.37

Activation of β-catenin/TCF targets following loss of the tumor suppressor SNF5. / Mora-Blanco, E. L.; Mishina, Y.; Tillman, E. J.; Cho, Yoon-Jae; Thom, C. S.; Pomeroy, S. L.; Shao, W.; Roberts, C. W.M.

In: Oncogene, Vol. 33, No. 7, 13.02.2014, p. 933-938.

Research output: Contribution to journalArticle

Mora-Blanco, EL, Mishina, Y, Tillman, EJ, Cho, Y-J, Thom, CS, Pomeroy, SL, Shao, W & Roberts, CWM 2014, 'Activation of β-catenin/TCF targets following loss of the tumor suppressor SNF5', Oncogene, vol. 33, no. 7, pp. 933-938. https://doi.org/10.1038/onc.2013.37
Mora-Blanco EL, Mishina Y, Tillman EJ, Cho Y-J, Thom CS, Pomeroy SL et al. Activation of β-catenin/TCF targets following loss of the tumor suppressor SNF5. Oncogene. 2014 Feb 13;33(7):933-938. https://doi.org/10.1038/onc.2013.37
Mora-Blanco, E. L. ; Mishina, Y. ; Tillman, E. J. ; Cho, Yoon-Jae ; Thom, C. S. ; Pomeroy, S. L. ; Shao, W. ; Roberts, C. W.M. / Activation of β-catenin/TCF targets following loss of the tumor suppressor SNF5. In: Oncogene. 2014 ; Vol. 33, No. 7. pp. 933-938.
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