TY - JOUR
T1 - Activation and trafficking of CD8 + T cells during viral skin infection
T2 - immunological lessons learned from vaccinia virus
AU - Hobbs, Samuel J.
AU - Osborn, Jossef F.
AU - Nolz, Jeffrey C.
N1 - Publisher Copyright:
© 2017 Elsevier B.V.
PY - 2018/2
Y1 - 2018/2
N2 - Epicutaneous delivery of vaccinia virus (VacV) by scarification of the skin generates robust and durable protective immunity, which was ultimately responsible for eradicating smallpox from the human race. Therefore, infection of the skin with VacV is often used in experimental model systems to study the activation of adaptive immunity, as well as the development and functional features of immunological memory. Here, we describe recent advances using this viral infection to identify and characterize the mechanisms regulating the activation and trafficking of cytotoxic CD8 + T cells into the inflamed skin, the migratory features of CD8 + T cells within the skin microenvironment, and finally, their subsequent differentiation into tissue-resident memory cells.
AB - Epicutaneous delivery of vaccinia virus (VacV) by scarification of the skin generates robust and durable protective immunity, which was ultimately responsible for eradicating smallpox from the human race. Therefore, infection of the skin with VacV is often used in experimental model systems to study the activation of adaptive immunity, as well as the development and functional features of immunological memory. Here, we describe recent advances using this viral infection to identify and characterize the mechanisms regulating the activation and trafficking of cytotoxic CD8 + T cells into the inflamed skin, the migratory features of CD8 + T cells within the skin microenvironment, and finally, their subsequent differentiation into tissue-resident memory cells.
UR - http://www.scopus.com/inward/record.url?scp=85032020421&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85032020421&partnerID=8YFLogxK
U2 - 10.1016/j.coviro.2017.10.001
DO - 10.1016/j.coviro.2017.10.001
M3 - Review article
C2 - 29080420
AN - SCOPUS:85032020421
SN - 1879-6257
VL - 28
SP - 12
EP - 19
JO - Current Opinion in Virology
JF - Current Opinion in Virology
ER -