Activation and trafficking of CD8+ T cells during viral skin infection: immunological lessons learned from vaccinia virus

Samuel J. Hobbs, Jossef F. Osborn, Jeffrey C. Nolz

Research output: Research - peer-reviewReview article

Abstract

Epicutaneous delivery of vaccinia virus (VacV) by scarification of the skin generates robust and durable protective immunity, which was ultimately responsible for eradicating smallpox from the human race. Therefore, infection of the skin with VacV is often used in experimental model systems to study the activation of adaptive immunity, as well as the development and functional features of immunological memory. Here, we describe recent advances using this viral infection to identify and characterize the mechanisms regulating the activation and trafficking of cytotoxic CD8+ T cells into the inflamed skin, the migratory features of CD8+ T cells within the skin microenvironment, and finally, their subsequent differentiation into tissue-resident memory cells.

LanguageEnglish (US)
Pages12-19
Number of pages8
JournalCurrent Opinion in Virology
Volume28
DOIs
StatePublished - Feb 1 2018

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Vaccinia virus
Virus Diseases
T-Lymphocytes
Skin
Immunologic Memory
Smallpox
Adaptive Immunity
Immunity
Theoretical Models
Infection

ASJC Scopus subject areas

  • Virology

Cite this

Activation and trafficking of CD8+ T cells during viral skin infection : immunological lessons learned from vaccinia virus. / Hobbs, Samuel J.; Osborn, Jossef F.; Nolz, Jeffrey C.

In: Current Opinion in Virology, Vol. 28, 01.02.2018, p. 12-19.

Research output: Research - peer-reviewReview article

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