TY - JOUR
T1 - Activation and repression in the nervous system
AU - Goodman, Richard H.
AU - Mandel, Gail
PY - 1998/6
Y1 - 1998/6
N2 - The mechanisms underlying transcriptional activation and repression have become much clearer. Recent evidence suggests that transcription factors that do not bind DNA directly, the co-activators and co-repressors, mediate a large number of cell signaling events. Their association with histone acetylases, to mediate activation, or deacetylases, to mediate repression, provide a model for explaining how gene expression is regulated.
AB - The mechanisms underlying transcriptional activation and repression have become much clearer. Recent evidence suggests that transcription factors that do not bind DNA directly, the co-activators and co-repressors, mediate a large number of cell signaling events. Their association with histone acetylases, to mediate activation, or deacetylases, to mediate repression, provide a model for explaining how gene expression is regulated.
UR - http://www.scopus.com/inward/record.url?scp=0032104047&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032104047&partnerID=8YFLogxK
U2 - 10.1016/S0959-4388(98)80069-X
DO - 10.1016/S0959-4388(98)80069-X
M3 - Article
C2 - 9687359
AN - SCOPUS:0032104047
SN - 0959-4388
VL - 8
SP - 413
EP - 417
JO - Current Opinion in Neurobiology
JF - Current Opinion in Neurobiology
IS - 3
ER -