Activation and repression in the nervous system

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

The mechanisms underlying transcriptional activation and repression have become much clearer. Recent evidence suggests that transcription factors that do not bind DNA directly, the co-activators and co-repressors, mediate a large number of cell signaling events. Their association with histone acetylases, to mediate activation, or deacetylases, to mediate repression, provide a model for explaining how gene expression is regulated.

Original languageEnglish (US)
Pages (from-to)413-417
Number of pages5
JournalCurrent Opinion in Neurobiology
Volume8
Issue number3
DOIs
StatePublished - Jun 1998

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Histone Acetyltransferases
Co-Repressor Proteins
Nervous System
Transcriptional Activation
Transcription Factors
Cell Count
Gene Expression
DNA

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Activation and repression in the nervous system. / Goodman, Richard; Mandel, Gail.

In: Current Opinion in Neurobiology, Vol. 8, No. 3, 06.1998, p. 413-417.

Research output: Contribution to journalArticle

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