Activation and repression in the nervous system

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Abstract

The mechanisms underlying transcriptional activation and repression have become much clearer. Recent evidence suggests that transcription factors that do not bind DNA directly, the co-activators and co-repressors, mediate a large number of cell signaling events. Their association with histone acetylases, to mediate activation, or deacetylases, to mediate repression, provide a model for explaining how gene expression is regulated.

Original languageEnglish (US)
Pages (from-to)413-417
Number of pages5
JournalCurrent Opinion in Neurobiology
Volume8
Issue number3
DOIs
StatePublished - Jun 1998

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ASJC Scopus subject areas

  • Neuroscience(all)

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