Action of the venom of the scorpion Tityus trinitatis on pancreatic insulin secretion

Hariharan Sankaran, Clifford Deveney, Courtney Bartholomew, Easwaran Raghupathy

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

In vivo, canine pancreas was stimulated to secrete insulin by the venom of the scorpion Tityus trinitatis; the venom also caused a rise in plasma glucose level as well. The venom-induced insulin secretion was also observed under in vitro conditions in rat pancreative slices, and this stimulation was dose-related. Maximal effect was observed at 20 μg/ml. Atropine (3 × 10-6 M) completely abolished both venom (20 μg/ml)- and acetylcholine (3 × 10-7 M)-induced insulin secretion. It is suggested that the venom-induced insulin secretion is mediated through muscarinic cholinergic mechanisms.

Original languageEnglish (US)
Pages (from-to)1101-1104
Number of pages4
JournalBiochemical Pharmacology
Volume32
Issue number6
DOIs
StatePublished - Mar 15 1983
Externally publishedYes

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Scorpion Venoms
Venoms
Insulin
Cholinergic Agents
Atropine
Acetylcholine
Canidae
Rats
Pancreas
Plasmas
Glucose

ASJC Scopus subject areas

  • Pharmacology

Cite this

Action of the venom of the scorpion Tityus trinitatis on pancreatic insulin secretion. / Sankaran, Hariharan; Deveney, Clifford; Bartholomew, Courtney; Raghupathy, Easwaran.

In: Biochemical Pharmacology, Vol. 32, No. 6, 15.03.1983, p. 1101-1104.

Research output: Contribution to journalArticle

Sankaran, Hariharan ; Deveney, Clifford ; Bartholomew, Courtney ; Raghupathy, Easwaran. / Action of the venom of the scorpion Tityus trinitatis on pancreatic insulin secretion. In: Biochemical Pharmacology. 1983 ; Vol. 32, No. 6. pp. 1101-1104.
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