In vivo, canine pancreas was stimulated to secrete insulin by the venom of the scorpion Tityus trinitatis; the venom also caused a rise in plasma glucose level as well. The venom-induced insulin secretion was also observed under in vitro conditions in rat pancreative slices, and this stimulation was dose-related. Maximal effect was observed at 20 μg/ml. Atropine (3 × 10-6 M) completely abolished both venom (20 μg/ml)- and acetylcholine (3 × 10-7 M)-induced insulin secretion. It is suggested that the venom-induced insulin secretion is mediated through muscarinic cholinergic mechanisms.
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