TY - JOUR
T1 - Action of the venom of the scorpion Tityus trinitatis on pancreatic insulin secretion
AU - Sankaran, Hariharan
AU - Deveney, Clifford W.
AU - Bartholomew, Courtney
AU - Raghupathy, Easwaran
N1 - Funding Information:
Acknowledgements--We thank A. Cullen for technical assistance, This work was supported by a grant from the Wellcome Trust, London; National Institutes of Health Grant NS 15659; and a Biomedical Research Support Grant RR05755 from the Langley Porter Psychiatric Institute, University of California, San Francisco.
PY - 1983/3/15
Y1 - 1983/3/15
N2 - In vivo, canine pancreas was stimulated to secrete insulin by the venom of the scorpion Tityus trinitatis; the venom also caused a rise in plasma glucose level as well. The venom-induced insulin secretion was also observed under in vitro conditions in rat pancreative slices, and this stimulation was dose-related. Maximal effect was observed at 20 μg/ml. Atropine (3 × 10-6 M) completely abolished both venom (20 μg/ml)- and acetylcholine (3 × 10-7 M)-induced insulin secretion. It is suggested that the venom-induced insulin secretion is mediated through muscarinic cholinergic mechanisms.
AB - In vivo, canine pancreas was stimulated to secrete insulin by the venom of the scorpion Tityus trinitatis; the venom also caused a rise in plasma glucose level as well. The venom-induced insulin secretion was also observed under in vitro conditions in rat pancreative slices, and this stimulation was dose-related. Maximal effect was observed at 20 μg/ml. Atropine (3 × 10-6 M) completely abolished both venom (20 μg/ml)- and acetylcholine (3 × 10-7 M)-induced insulin secretion. It is suggested that the venom-induced insulin secretion is mediated through muscarinic cholinergic mechanisms.
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U2 - 10.1016/0006-2952(83)90632-9
DO - 10.1016/0006-2952(83)90632-9
M3 - Article
C2 - 6340691
AN - SCOPUS:0020628751
SN - 0006-2952
VL - 32
SP - 1101
EP - 1104
JO - Biochemical Pharmacology
JF - Biochemical Pharmacology
IS - 6
ER -