@article{92e74fec82924a5686299b88e3783eaa,
title = "Actinomycin D induced DNAse I cleavage enhancement caused by sequence specific propagation of an altered DNA structure",
abstract = "Two DNA hexadecamers containing one central 5′-GC-3′ base step have been examined by footprinting methodology in the presence and absence of actinomycin D. The results of these studies, coupled with imino proton NMR measurements indicate that the antitumor drug causes a change in DNA conformation at a distance from the actinomycin intercalation site in a molecule of sequence d[ATATATAGCTATATAT] that does not occur in d[AAAAAAAGCTTTTTTT] The experiments demonstrate that DNase I rate enhancements associated with actinomycin D binding are caused by ligand alteration of equilibrium DNA structure.",
author = "Huang, {Yao Qi} and Rehfuss, {Robert P.} and Laplante, {Steven R.} and Ellis Boudreau and Borer, {Philip N.} and Lane, {Michael J.}",
note = "Funding Information: Acknowledgements We thank T. Tullius, P. Hahn, P.G. Waterbury, A. Smardon, D.G. Hanlon, and R. Morse for critical reading of versions of this manuscript, M. Rubert for artistic help and J.C. Dabrowiak for use of his densitometer. This work was supported by the Hematology/Oncology Division, SUNY-HSC, a grant from the Department of Medicine, SUNY-HSC (H.-Q. H) , the Hendricks Foundation for Medical Research, NIH grants GM35069, RR01317 (G.C. Levy and P.N.B.), and NCI grant CA45698 (M.J.L.).",
year = "1988",
month = dec,
day = "9",
doi = "10.1093/nar/16.23.11125",
language = "English (US)",
volume = "16",
pages = "11125--11139",
journal = "Nucleic acids research",
issn = "0305-1048",
publisher = "Oxford University Press",
number = "23",
}