Actigraphy- and Polysomnography-Measured Sleep Disturbances, Inflammation, and Mortality Among Older Men

for the Osteoporotic Fractures in Men (MrOS) Research Group

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

OBJECTIVES: To evaluate whether objectively measured sleep characteristics are associated with mortality risk independent of inflammatory burden and comorbidity. METHODS: The Osteoporotic Fractures in Men Sleep Study (conducted in 2003–2005) included community-dwelling older men (n = 2531; average [standard deviation {SD}] age = 76.3 (5.5) years). Sleep measures from in-home polysomnography and wrist actigraphy and assessments of serum inflammatory markers levels (C-reactive protein, interleukin-6, tumor necrosis factor α, tumor necrosis factor α soluble receptor II, and interferon-γ) were obtained. Vital status was ascertained over an average (SD) follow-up of 7.4 (1.9 SD) years. RESULTS: Three of the seven main sleep measures examined were independently associated with greater inflammatory burden. Mortality risk associated with prolonged (≥10% total sleep time) blood oxygen desaturation and short (

Original languageEnglish (US)
JournalPsychosomatic Medicine
DOIs
StateAccepted/In press - Feb 18 2016

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Actigraphy
Polysomnography
Sleep
Inflammation
Mortality
Independent Living
Osteoporotic Fractures
Tumor Necrosis Factor Receptors
Wrist
C-Reactive Protein
Interferons
Comorbidity
Interleukin-6
Tumor Necrosis Factor-alpha
Biomarkers
Oxygen
Deviation

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Applied Psychology
  • Arts and Humanities (miscellaneous)
  • Developmental and Educational Psychology

Cite this

Actigraphy- and Polysomnography-Measured Sleep Disturbances, Inflammation, and Mortality Among Older Men. / for the Osteoporotic Fractures in Men (MrOS) Research Group.

In: Psychosomatic Medicine, 18.02.2016.

Research output: Contribution to journalArticle

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